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Contribution to the study of hepatoprotective activity of tinospora bakis miers menispermaceae



Contribution to the study of hepatoprotective activity of tinospora bakis miers menispermaceae



Afrique Medicale 27(266): 401-406



The antijaundice and hepatoprotective properties of Tinospora bakis were verified through a pharmacological, biochemical and histological study. Tests were carried out on the preventive and curative effect of T. bakis extract on the biochemical and histological modifications caused by acute and subacute carbon tetrachloride intoxication. Its influence on sulfobromophthalein (BSP) clearance was also evaluated. Preventive treatment of rats with the plant extract attenuated the biochemical alterations right from the start, and the alterations disappeared by the fourth day, as did the histological lesions in guinea pigs. The appearance time of BSP was significantly reduced. On the other hand, treatment of rats with the T. bakis extract after acute intoxication led to a qualitative attenuation of the histological lesions and biochemical alterations. Complete recuperation seemed difficult, but came between the eighth and tenth days. These results justify the use of T. bakis in folk medicine as an antijaundice plant and suggest that a galenic formula be prepared for greater diffusion.

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