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Corneal endothelial changes in experimental radial keratotomy and their treatment with bendazac lysine a controlled clinical and electron microscopic study



Corneal endothelial changes in experimental radial keratotomy and their treatment with bendazac lysine a controlled clinical and electron microscopic study



Current Therapeutic Research 52(1): 53-63



Changes of corneal thickness and endothelial ulstrastructure of rabbit eyes after radial keratotomy as well as effects of prednisolone and bendazac-lysine on keratectomized corneas were studied. The corneaal thickness increased after keratotomy and the maximum values of control axes were measured on the seventh day postoperatively; they returned to normal after 2 months. Swelling of mitochondria, disappearance of cristae, increased synthetic activity, and elaboration of cell junction were found with electron microscope. We conclude that direct trauma or postoperative inflammation plays a minor role in the pathogenesis of endothelial alterations, while elaboration of free radicals during normal regenerating processes may be a principal cause of endothelial changes. Prednisolone treatment was ineffective in preventing the development of corneal edema and endothelial alterations. Bendazac-lysine treatment decreased both corneal edema and endothelial changes.

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Accession: 007162077

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