+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cortical versus medullary thymomas: a useful morphologic distinction?

Cortical versus medullary thymomas: a useful morphologic distinction?

Human Pathology 19(11): 1335-1339

We have tested the hypothesis that thymomas can be classified solely on the basis of epithelial cell morphology and that this distinction is prognostically useful. One hundred thymic epithelial tumors were classified according to the morphologic resemblance to cortical or medullary thymic epithelium and to the traditional classification (lymphocytic, epithelial, mixed, and spindled). Follow-up data was obtained on 78 patients. Fifty-eight percent of the tumors were invasive. Nineteen of the invasive tumors relapsed and none of the non-invasive tumors relapsed (P < .0001). Four of nine tumors with microscopic invasion through the capsule recurred. Statistically analysis showed no significant differences in relapse-free survival for any of the histologic categories. Ninety-four percent of the tumors studied were keratin positive and all were chromogranin negative. Carcinoembryonic antigen was negative for all but one cytologically malignant tumor; of the tumors 75% were epithelial membrane antigen positive, 80% were Leu-7 positive, and 11% were neuron specific enolase positive. Seven of 12 tumors tested expressed HLA-DR. There was no correlation between immunoreactivity and classification. The morphologic cortical/medullary distinction is conceptually attractive but appears clinically to be no more advantageous than the traditional classification.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 007165033

Download citation: RISBibTeXText

PMID: 3181952

DOI: 10.1016/s0046-8177(88)80289-2

Related references

Cortical versus medullary thymomas a useful morphologic classification?. Laboratory Investigation 58(1): 50A, 1988

Cortical versus medullary thymomas. Human Pathology 20(7): 715-716, 1989

Expression of cortical and medullary thymic epithelial antigens in thymomas. An immunohistological study of 14 cases including a characterization of the lymphocytic compartment. Histopathology 14(5): 447-463, 1989

MR in renal disease: importance of cortical-medullary distinction. Magnetic Resonance in Medicine 5(2): 160-172, 1987

Thymomas with medullary aplasia. Acta Tuberculosea et Pneumologica Belgica 56(3): 204-212, 1965

Medullary differentiation and distribution of idrcs in thymomas. Journal of Pathology 152(3): 203A, 1987

Usefulness of morphometric evaluation and silver nucleolar organizer region technique in making the distinction between myasthenic and nonmyasthenic thymomas. Journal of the Neurological Sciences 150(SUPPL ): S54, 1997

Does Medullary Versus Cortical Invasion of the Mandible Affect Prognosis in Patients With Oral Squamous Cell Carcinoma?. Journal of Oral and Maxillofacial Surgery, 2016

Comparative morphologic and immunohistochemical investigation of spontaneously occurring thymomas in a colony of European hamsters. Veterinary Pathology 41(4): 346-352, 2004

Reaming versus non-reaming in medullary nailing: interference with cortical circulation of the canine tibia. Archives of Orthopaedic and Trauma Surgery 109(6): 314-316, 1990

Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow. American Journal of Physiology. Renal Physiology 290(3): F688-F694, 2005

Intrathymic presentation of extrathymic antigens in situ cortical epithelial cells versus medullary dendritic cells. Journal of Cellular Biochemistry Supplement (16 PART D): 78, 1992

Cortical medullary gradient for ammonia mechanism regulating formation of ammonium in medullary collecting duct. Kidney International 21(1): 240, 1982

Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. Plos Genetics 7(11): E1002348-E1002348, 2012

BCL-6, BCL-2 and BCL-XL protein expression by intratumoral thymocytes in cortical and mixed thymomas. Laboratory Investigation 81(1): 167A, January, 2001