+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Corticosteroid induced growth hormone secretion in normal and obese subjects



Corticosteroid induced growth hormone secretion in normal and obese subjects



Clinical Endocrinology 35(6): 485-490



OBJECTIVE: In normal subjects, corticosteroids stimulate growth hormone (GH) secretion at 3 hours. Obesity is associated with blunted GH secretion. In order to clarify both the deranged mechanism of GH secretion in obesity and the corticosteroid mechanism of action we have assessed in normal and obese subjects the effects of dexamethasone, pyridostigmine (a drug capable of suppressing somatostatin release) and GHRH. We also compared in normal subjects the stimulatory effect of three different corticosteroids on plasma GH levels. DESIGN: In both normal and obese subjects the following tests were carried out: placebo; dexamethasone alone (4 mg i.v. at 0 minutes); and dexamethasone plus pyridostigmine (120 mg p.o. at 60 minutes). In normal subjects we also studied the effects of hydrocortisone (100 mg i.v. at 0 minutes) and deflazacort (a corticosteroid that does not cross the blood-brain barrier) (60 mg i.v. at 0 minutes). In obese subjects we also assessed the effect of dexamethasone plus GHRH (100 .mu.g i.v. at 150 minutes) on plasma GH levels. PATIENTS: Ten normal subjects and 22 obese subjects were studied. Normal controls were within 10% of their ideal body weight. Obese subjects had a body mass index of 37.1 .+-. 1.1 (mean .+-. SEM). MEASUREMENTS: Plasma GH levels were measured by radioimmunoassay. RESULTS: Dexamethasone-induced GH secretion in normal subjects (28.6 .+-. 7.8 m .mu./l, P < 0.05). Corticosteroids did not alter GH levels in obese subjects. Pretreatment with pyridostigmine increased dexamethasone-induced GH release in normal subjects (40.8 .+-. 6.8 m .mu./l) but this did not achieve statistical significance. Dexamethasone plus pyridostigmine did not alter GH levels in obese subjects (8.0 .+-. 1.6 mU/l). In some subjects, dexamethasone pretreatment potentiated GHRH-stimulated GH secretion, while in half the subjects the basal GH levels were not altered. In control subjects, hydrocortisone and deflazacort caused GH release similar to dexamethasone. CONCLUSIONS: Corticosteroids are a new and selective stimulus of GH secretion. They do not cause GH release in obese subjects. Their relative independence from cholinergic control suggest that they act by reducing somatostatin secretion.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 007165109

Download citation: RISBibTeXText

PMID: 1769129


Related references

Effects of nicotinic acid on the secretion of growth hormone in normal and obese subjects. Bollettino Societa Italiana Biologia Sperimentale 50(13): (1975) 953-959, 1974

Normal sweat secretion despite impaired growth hormone-insulin-like growth factor-I axis in obese subjects. International Journal of Endocrinology 2011: 493840, 2011

Sex-related naloxone influence on growth hormone-releasing hormone-induced growth hormone secretion in normal subjects. Metabolism: Clinical and Experimental 36(2): 105-109, 1987

Sex related naloxone influence on growth hormone releasing factor induced growth hormone secretion in normal subjects. Journal of Endocrinological Investigation 8(Suppl. 3): 170, 1985

Comparison of growth hormone releasing factor induced growth hormone secretion in acromegalics and normal subjects. Hormone Research 24(2-3): 193, 1986

Stimulation tests for growth hormone. A comparison between insulin-induced hypoglycaemia and levodopa as stimuli for growth hormone secretion in patients with hypothalamic-pituitary insufficiency and in normal subjects. Danish Medical Bulletin 26(6): 304-308, 1979

Stimulation tests for growth hormone comparison between insulin induced hypo glycemia and l dopa as stimuli for growth hormone secretion in patients with hypothalamic pituitary insufficiency and in normal subjects. Acta Endocrinologica Supplementum 212: 230, 1977

Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. Journal of Clinical Endocrinology and Metabolism 70(5): 1361-1370, 1990

CCK-8 antagonizes apomorphine-induced growth hormone secretion in normal subjects. Hormone and Metabolic Research 18(1): 53-55, 1986

Effect of enhancement of endogenous cholinergic tone with pyridostigmine on the dose-response relationships of growth hormone (GH)-releasing hormone-induced GH secretion in normal subjects. Journal of Clinical Endocrinology and Metabolism 70(2): 324-327, 1990

Effect of L-tryptophan on apomorphine-induced growth hormone secretion in normal subjects. Pharmakopsychiatrie, Neuro-Psychopharmakologie 13(6): 331-335, 1980

Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial. Journal of Clinical Endocrinology and Metabolism 97(12): 4769-4779, 2012

Effect of growth hormone releasing factor grf on growth hormone gh secretion during short term restriction of energy intake in obese subjects. Clinical & Investigative Medicine 11(4 Suppl.): C34, 1988

Effect of hydrocortisone on basal and apomorphine-induced growth hormone secretion in normal subjects. Clinical and Investigative Medicine. Medecine Clinique et Experimentale 11(3): 218-223, 1988

Serum growth hormone response to exercise in non-obese and obese normal subjects. Scandinavian Journal of Clinical and Laboratory Investigation 31(2): 175-178, 1973