+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Corticosteroids increase lipocortin I in alveolar epithelial cells

Corticosteroids increase lipocortin I in alveolar epithelial cells

American Journal of Respiratory Cell and Molecular Biology 3(4): 349-353

Lipocortin I mediates, in part, the anti-inflammatory effects of corticosteroids. To determine whether alveolar epithelial cells produce lipocortin I, we used a highly specific anti-lipocortin I antibody and found by the techniques of Western blotting and immunocytochemical analysis that lipocortin I is a normal constituent of type II alveolar epithelial cells and that it constitutes approximately 0.1% of cell lysate proteins. Two separate species of lipocortin I were identified, migrating with molecular weights of 37 and 32 kD. Dexamethasone caused a dose-dependent increase in lipocortin I in rat alveolar epithelial cells, and its effect was maximal at a dose of 10(-5) M. This effect was specific for corticosteroids since it was not seen with other steroids. These studies suggest that lipocortin I may mediate, in part, the immunosuppressive effects of corticosteroids in the lower respiratory tract.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 007165152

Download citation: RISBibTeXText

PMID: 2144977

DOI: 10.1165/ajrcmb/3.4.349

Related references

Lipocortin i is produced by type ii alveolar epithelial cells. Clinical Research 37(2): 473A, 1989

Corticosteroids increase lipocortin I in Bal fluid from normal individuals and patients with lung disease. Journal of Applied Physiology 68(4): 1668-1671, 1990

Corticosteroids increase lipocortin I in BAL fluid from normal individuals and patients with lung disease. Journal of Applied Physiology 68(4): 1668-1671, 1990

Experimental radiation pneumonitis. Corticosteroids increase the replicative activity of alveolar type 2 cells. Radiation Research 115(3): 543-549, 1988

Evaluation of alveolar epithelial cells in the sheep model of congenital diaphragmatic hernia: Type 1 alveolar epithelial cells and histopathological image analysis. Journal of Pediatric Surgery 52(12): 2074-2077, 2017

The efficiency of the translocation of Mycobacterium tuberculosis across a bilayer of epithelial and endothelial cells as a model of the alveolar wall is a consequence of transport within mononuclear phagocytes and invasion of alveolar epithelial cells. Infection and Immunity 70(1): 140-146, 2002

The Efficiency of the Translocation of Mycobacterium tuberculosis across a Bilayer of Epithelial and Endothelial Cells as a Model of the Alveolar Wall Is a Consequence of Transport within Mononuclear Phagocytes and Invasion of Alveolar Epithelial Cells. Infection and Immunity 70(1): 140-146, 2002

Corticosteroids increase secretory leukocyte protease inhibitor transcript levels in airway epithelial cells. American Journal of Physiology 268(4 Pt 1): L601-L606, 1995

Analysis of gene expression profiles in alveolar epithelial type II-like cells differentiated from human alveolar epithelial progenitor cells. Respiratory Investigation 50(3): 110-116, 2012

Phenotypic characterization of alveolar capillary endothelial cells alveolar epithelial cells and alveolar macrophages in patients with pulmonary fibrosis with special reference to mhc class ii antigens. Virchows Archiv A Pathological Anatomy & Histopathology 415(1): 79-90, 1989

Protease-activated receptor-2 -mediated increase in neutrophil adhesion to alveolar epithelial cells. Journal of Pharmacological Sciences 91(Suppl. I): 251P, 2003

Nuclear Fos/Jun ratios and AP-1 activity increase in alveolar epithelial cells during repair of hyperoxic lung injury. FASEB Journal 7(3-4): A218, 1993

Proinflammatory Cytokines Increase Vascular Endothelial Growth Factor Expression in Alveolar Epithelial Cells. Mediators of Inflammation 2015: 387842, 2015

Assembly of basement membrane in vitro by alveolar epithelial cells and fibroblasts and reconstruction of an alveolar epithelial tissue on the BM. Japanese Journal of Pharmacology 73(Suppl. 1): 22P, 1997

Urokinase plasminogen activator released by alveolar epithelial cells modulates alveolar epithelial repair in vitro. Thrombosis and Haemostasis 94(6): 1257-1264, 2005