+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Corticosterone differentially regulates the bilateral response of astrocyte messenger rnas in the hippocampus to entorhinal cortex lesions in male rats



Corticosterone differentially regulates the bilateral response of astrocyte messenger rnas in the hippocampus to entorhinal cortex lesions in male rats



Molecular Brain Research 10(4): 291-298



This study examined the effect of adrenalectomy (ADX) and corticosterone (CORT) replacement on the levels of two astrocyte mRNAs during responses to unilateral entorhinal cortex lesions (ECL) to identify molecular mechanisms involved in glucocorticoid modulation of astrocyte activation following deafferentation. Both glial fibrillary acidic protein (GFAP) and sulfated glycoprotein-2 (SGP-2) mRNA were increased in the ipsilateral hippocampus 4 days following unilateral ECL. In unlesioned ADX rats CORT replacement decreased both messages in the hippocampus. CORT replacement suppressed the ECL-induced increase of GFAP mRNA in the contralateral, but not ipsilateral hippocampus of ADX rats. In contrast, CORT decreased SGP-2 mRNA both ipsi- and contralaterally. It is clear that several regulatory mechanisms are responsible for maintaining a physiological balance of astrocyte activity in the adult brain, and that changes in circuit integrity and the endocrine milieu can alter this balance.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 007165174

Download citation: RISBibTeXText


Related references

Corticosterone differentially regulates the bilateral response of astrocyte mRNAs in the hippocampus to entorhinal cortex lesions in male rats. Brain Research. Molecular Brain Research 10(4): 291-297, 1991

Corticosterone decreases glial fibrillary acidic protein messenger rna and sulfated glycoprotein 2 messenger rna in the hippocampus of adrenalectomized and entorhinal cortex lesioned male rats. Society for Neuroscience Abstracts 16(1): 659, 1990

Selective neurodegeneration of hippocampus and entorhinal cortex correlates with spatial learning impairments in rats with bilateral ibotenate lesions of ventral subiculum. Brain Research 960(1-2): 9-15, 2002

Selective neurodegeneration of hippocampus and entorhinal cortex correlates with spatial learning impairments in rats with bilateral ibotenate lesions of ventral subiculum. Brain Research 960(1-2): 9-15, 17 January, 2003

Increases in transforming growth factor-beta mRNA in hippocampus during response to entorhinal cortex lesions in intact and adrenalectomized rats. Journal of Neuroscience Research 28(1): 134-139, 1991

Effects of entorhinal lesions on trophic activities present in rat entorhinal cortex and hippocampus as studied using primary cultures of entorhinal and septal tissues. Journal of Neuroscience Research 18(2): 274-288, 1987

Bilateral lesions of the entorhinal cortex differentially modify haloperidol- and olanzapine-induced c-fos mRNA expression in the rat forebrain. Neuropharmacology 45(2): 190-200, 2003

Testosterone differentially regulates expression of GnRH messenger RNAs in the terminal nerve, preoptic and midbrain of male tilapia. Molecular Brain Research 60(1): 13-20, Sept 18, 1998

Bilateral changes in glutamate uptake muscarinic receptor binding and acetylcholinesterase level in the rat hippocampus after unilateral entorhinal cortex lesions. Neurochemistry International 9(2): 255-264, 1986

The entorhinal cortex regulates blood glucose level in response to microinjection of neostigmine into the hippocampus. Neuro Endocrinology Letters 26(3): 225-230, 2005

Corticosterone differentially regulates the expression of Gs alpha and Gi alpha messenger RNA and protein in rat cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America 86(10): 3906-3910, 1989

Acquisition of a complex place task in rats with selective ibotenate lesions of hippocampal formation: combined lesions of subiculum and entorhinal cortex versus hippocampus. Behavioral Neuroscience 102(6): 828-834, 1988

Neuroimmune response in the neonatal mouse hippocampus following prenatal lesions to the entorhinal cortex. Society for Neuroscience Abstracts 18(1-2): 626, 1992

Bilateral entorhinal cortex lesions impair DRL performance in rats. Psychobiology. 23(1): 37-44, 1995

Astrocytic apolipoprotein e messenger rna and gfap messenger rna in hippocampus after entorhinal cortex lesioning. Molecular Brain Research 11(2): 97-106, 1991