+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Corticotropin effects on blood pressure and fluid and electrolyte homeostasis in five strains of rats

Corticotropin effects on blood pressure and fluid and electrolyte homeostasis in five strains of rats

American Journal of Hypertension 5(5 Pt 1): 302-313

The hemodynamic and metabolic effects of 11 days of sham (saline) and corticotropin injection were examined in five different strains of rats: Sprague-Dawley, spontaneously hypertensive (SHR), Wistar-Kyoto (WKY), Brattleboro, and Long Evans. Corticotropin significantly increased systolic blood pressure (SBP) compared with sham injection in all strains: final SBP in Sprague-Dawley was 108 .+-. 5 mm Hg corticotropin, 94 .+-. 4 mm Hg sham; SHR 146 .+-. 6 mm Hg corticotropin, 141 .+-. 3 mm Hg sham; WKY 117 .+-. 3 mm Hg corticotropin, 103 .+-. 3 mm Hg sham; Brattleboro 108 .+-. 5 mm Hg corticotropin, 93 .+-. 2 mm Hg sham; and Long Evans 103 .+-. 5 mm Hg corticotropin, 90 .+-. 4 mm Hg sham (P < .001). Corticotropin also produced a decrease in body weight and increases in water intake and urine output. Increases in urine electrolyte excretion were seen in some, but not all strains. The rise in pressure in the Brattleboro rats indicated that vasopressin is not essential for the corticotropin-induced rise in pressure. Blood pressure rises in SHR were not exaggerated. Withdrawal of corticotropin in Sprague-Dawley rats led to rapid reversal of the corticotropin-induced hemodynamic and metabolic changes. Thus, strain does not appear to be an important factor in corticotropin hypertension in the rat, in contrast to deoxycorticosterone hypertension.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 007165213

Download citation: RISBibTeXText

PMID: 1316127

Related references

Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats. American Journal of Physiology. Renal Physiology 295(6): F1752-F1763, 2008

The effects of captopril on blood pressure and fluid and electrolyte balance in rats made hypertensive by isolation. Journal of Pharmacy and Pharmacology 34(3): 188-190, 1982

Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure. Hypertension 62(1): 91-98, 2013

Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis. New England Journal of Medicine 314(13): 828-834, 1986

Effects of high sugar diets on renal fluid, electrolyte and mineral handling in rats: relationship to blood pressure. Journal of the American College of Nutrition 13(1): 73-82, 1994

Atrial natriuretic peptide in the locus coeruleus and its possible role in the regulation of arterial blood pressure, fluid and electrolyte homeostasis. Life Sciences 49(12): 869-879, 1991

Effects of intracerebroventricular atrial natriuretic peptide immunoneutralization on the fluid-electrolyte homeostasis in conscious unrestrained Wistar rats. Pfluegers Archiv European Journal of Physiology 430(4 SUPPL ): R106, 1995

NO and angiotensin II effects on blood pressure and fluid homeostasis. Journal of Neuroendocrinology 9(7): 545-552, 1997

Sodium bicarbonate and sodium chloride: effects on blood pressure and electrolyte homeostasis in normal and hypertensive man. Journal of Hypertension 8(7): 663-670, 1990

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. Journal of Clinical Investigation 123(7): 2803-2815, 2013

Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis. Cellular Signalling 26(6): 1166-1172, 2014

High blood pressure effects on the blood to cerebrospinal fluid barrier and cerebrospinal fluid protein composition: a two-dimensional electrophoresis study in spontaneously hypertensive rats. International Journal of Hypertension 2013: 164653-164653, 2013

Hypothalamic endothelin: presence and effects related to fluid and electrolyte homeostasis. Journal of Cardiovascular Pharmacology 17 Suppl 7: S346-S349, 1991

Three levels of dietary calcium-effects on blood pressure and electrolyte balance in spontaneously hypertensive rats. Naunyn-Schmiedeberg's Archives of Pharmacology 346(5): 542-549, 1992

Time related aspects of arterial blood pressure, plasma volume, and electrolyte homeostasis in man. International Journal of Chronobiology 1(1): 25-30, 1973