+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats



Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats



Life Sciences 49(19): 1427-1434



Corticotropin releasing factor (CRF) both stimulates ACTH secretion from the pituitary and inhibits secretion of growth hormone (GH) in adult rats through actions in the CNS. The purpose of the present study was to evaluate these pituitary and central actions of CRF in neonatal rats, in which the hypothalamo- pituitary adrenal (HPA) axis is relatively hypo-functional. The results of this study show that central or peripheral administration of CRF evokes a marked dose-related rise in serum corticosterone in 6-day old rats. The same doses of CRF stimulate, rather than inhibit GH secretion. These results suggest that CRF has unique central actions early in ontogeny.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 007165275

Download citation: RISBibTeXText

PMID: 1943449

DOI: 10.1016/0024-3205(91)90395-r


Related references

Effects of corticotropin releasing factor and growth hormone releasing factor on pituitary hormone secretion in patients with congenital thyrotropin deficiency. Abnormal response of growth hormone to corticotropin releasing factor. Hormone and Metabolic Research 18(12): 849-853, 1986

Interaction of vasoactive intestinal peptide (VIP) and growth hormone releasing factor (GRF) with corticotropin releasing factor (CRF) on corticotropin secretion in vitro. Neuropeptides 12(3): 131-133, 1988

Somatocrinin growth hormone releasing factor stimulates secretion of growth hormone in anesthetized rats. Biochemical & Biophysical Research Communications 109(2): 382-387, 1982

Intravenous administration of tumor necrosis factor-alpha stimulates corticotropin releasing hormone secretion in the push-pull cannulated median eminence of freely moving rats. Neuropeptides 22(2): 81-84, 1992

Galanin stimulates growth hormone (GH) secretion via GH-releasing factor (GRF) in conscious rats. European Journal of Pharmacology 136(3): 415-418, 1987

Corticotropin-releasing factor stimulates secretion of melanocyte-stimulating hormone from the rat pituitary. Science 217(4554): 62-63, 1982

Nitric oxide stimulates ACTH secretion and the transcription of the genes encoding for NGFI-B, corticotropin-releasing factor, corticotropin-releasing factor receptor type 1, and vasopressin in the hypothalamus of the intact rat. Journal of Neuroscience 19(17): 7640-7647, 1999

Effect of corticotropin releasing factor injected into the Median Eminence on growth hormone secretion in male rats. Neurochemical Research 24(6): 715-718, 1999

Platelet activating factor stimulates hypothalamic corticotropin releasing hormone secretion in vitro. Society for Neuroscience Abstracts 13(3): 1622, 1987

Involvement of Hypothalamic Somatostatin in the Suppression of Growth Hormone Secretion by Central Corticotropin-Releasing Factor in Conscious Male Rats. Neuroendocrinology 41(5): 390-393, 2008

Involvement of hypothalamic somatostatin in the suppression of growth hormone secretion by central corticotropin-releasing factor in conscious male rats. Neuroendocrinology 41(5): 390-393, 1985

Effects of Intracerebroventricular Administration of Growth Hormone-Releasing Factor and Corticotropin-Releasing Factor on Somatostatin Secretion into Rat Hypophysial Portal Blood. Neuroendocrinology 51(1): 93-96, 1990

Effects of intracerebroventricular administration of growth hormone-releasing factor and corticotropin-releasing factor on somatostatin secretion into rat hypophysial portal blood. Neuroendocrinology 51(1): 93-96, 1990

Tumor necrosis factor alpha stimulates corticotropin releasing hormone secretion by explanted rat hypothalami in vitro. Society for Neuroscience Abstracts 14(1): 756, 1988

The phi phi 27 corticotropin releasing factor enkephalin immuno reactive hypothalamic neuron possible morphological basis for integrated control of prolactin corticotropin and growth hormone secretion. Proceedings of the National Academy of Sciences of the United States of America 80(3): 895-898, 1983