+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cortisol and alpha 2 adrenergic regulation of sympathoneural activity

Cortisol and alpha 2 adrenergic regulation of sympathoneural activity

Biogenic Amines 7(5): 445-454

Alpha-2 adrenoceptor regulation of sympathoneural function was assessed in conscious, unrestrained Wistar-Kyoto rats during chronic glucocorticoid treatment. Cortisol administered for seven days via a subcutaneous reservoir pump increased blood pressure, decreased body weight and decreased plasma norepinephrine (NE) levels. In untreated animals, intravenous administration of the alpha-2 adrenoceptor antagonist, yohimbine, increased plasma levels of NE and of dihydroxyphenylglycol (DHPG), the main intraneuronal metabolite of NE. Cortisol treatment abolished these responses to yohimbine. Intravenous administration of clonidine, an agonist at alpha-2 adrenoceptors, decreased plasma NE levels; cortisol treatment did not affect the proportionate decreases in NE and DHPG levels produced by clonidine or alter the inhibitory effect of clonidine on reflexive catecholamine responses induced by sodium-nitroprusside. The results suggest that hypercortisolemia suppresses sympathetic activity and may also interfere indirectly with central neural noradrenergic mechanisms regulating sympathoneural outflow.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 007165321

Download citation: RISBibTeXText

Related references

Chronic alpha-1-adrenergic blockade increases sympathoneural but not adrenomedullary activity in patients with essential hypertension. Journal of Hypertension 13(12 Pt 2): 1837-1841, 1995

Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting alpha-adrenergic activity. Synthesis and alpha-1- and alpha-2-adrenergic activity of 3-phenyl-3-piperidinols and their desoxy analogs. European Journal of Medicinal Chemistry 30(11): 869-880, 1995

Characterization of alpha-adrenergic receptor subtypes in the rat renal cortex. Differential regulation of alpha 1- and alpha 2-adrenergic receptors by guanyl nucleotides and Na. Molecular Pharmacology 22(3): 532-546, 1982

Density dependent regulation of the skeletal alpha actin and alpha myosin heavy chain genes by beta adrenergic and alpha 1 adrenergic pathways during myocardiocyte hypertrophy. Journal of Cellular Biochemistry Supplement (15 PART C): 192, 1991

Regulation of DNA polymerase alpha activity by the alpha 1-adrenergic receptors in proliferatively activated rat liver cells. Biochemical and Biophysical Research Communications 177(3): 973-978, 1991

Differential regulation of G protein alpha-subunit GTPase activity by peptides derived from the third cytoplasmic loop of the alpha 2-adrenergic receptor. Febs Letters 365(1): 13-17, 1995

Differential adrenergic regulation of rat pineal cyclic AMP production and N-acetyltransferase activity during postnatal development: involvement of G alpha s and G alpha i1-2 proteins. Journal of Endocrinology 155(2): 305-312, 1998

Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum. International Journal of Impotence Research 12 Suppl 1: S20-S25, 2000

Adrenergic regulation of neonatal brown fat adenylyl cyclase and Gs alpha activity. American Journal of Physiology 263(1 Pt 2): R34-R38, 1992

Bidirectional regulation of Na+,K(+)-ATPase activity by dopamine and an alpha-adrenergic agonist. Proceedings of the National Academy of Sciences of the United States of America 90(1): 21-24, 1993

Alpha(1)-adrenergic and alpha(2)-adrenergic balance in the dorsal pons and gross behavioral activity of mice in a novel environment. Psychopharmacology 183(1): 127-132, 2005

Regulation of a myosin isoform by an alpha 1 adrenergic receptor is independent of contractile activity. American Heart Association Monograph (124): II-80, 1986

Alpha 2-adrenergic agonist and alpha 1-adrenergic antagonist activity of ergotamine and dihydroergotamine in rats. Archives Internationales de Pharmacodynamie et de Therapie 284(1): 30-37, 1986

Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia. Anesthesiology 110(2): 401-407, 2009

Involvement of alpha- and beta-adrenergic receptors in the regulation of rat pineal N-acetyltransferase activity during development. Endocrinology 132(1): 393-398, 1993