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Cortisol glucagon and catecholamine variations during surgical stress differences between neurolept and isoflurane anesthesia

Cortisol glucagon and catecholamine variations during surgical stress differences between neurolept and isoflurane anesthesia

Acta Anaesthesiologica Italica 40(1): 23-28

Perioperative cortisol, glucagon and catecholamine changes after two different anaesthesia regimens - NLA II and Isoflurane - were studied in 56 patients undergoing abdominal and urological surgery. Conventional doses of isoflurane and neurolept drugs were employed. Cortisol and glucagon were monitored by means of three blood samples taken 24 hours before surgery, at the end of the operation and 24 hours after; catecholamines were measured as urine metabolites (VWA). The data obtained showed that there was no significant difference between neurolept and isoflurane anaesthesia as regards VMA perioperative changes. On the contrary, plasma cortisol values increased significantly in the isoflurane groups and plasma glucagon concentration increased in the neurolept group at the end of surgical procedure. The authors conclude that, since cortisol and glucagon are considered "stress hormones", neither NLA II nor Isoflurane anaesthesia in conventional doses, prevent endocrine metabolic responses to surgery.

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