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Cortisol response to metoclopramide in hyperprolactinemic women with pituitary microadenoma and women with hypothalamic amenorrhea



Cortisol response to metoclopramide in hyperprolactinemic women with pituitary microadenoma and women with hypothalamic amenorrhea



Japanese Journal of Fertility & Sterility 34(2): 82-84



Metoclopramide (MCP) can stimulate cortisol secretion in humans. It may stimulate cortisol secretion through an antidopaminergic mechanism or by a stress-mediated mechanism. In the present study, cortisol responses to MCP were evaluated in hyperprolactinemic women with pituitary microadenoma and women with hypothalmic amenorrhea. The intravenous administration of MCP induced no discernible change in cortisol levels in normal women during the early follicular phase. In contrast, an increase in serum cortisol levels were observed following MCP administration in hyperprolactinemic women with pituitary microadenoma and women with hypothalamic amenorrhea. The positive cortisol response to MCP may be related to the increased endogenous dopaminergic tone which is considered to be operative in these patients.

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Accession: 007165389

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