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Cost effectiveness of gamete intrafallopian transfer in comparison with induction of ovulation with gonadotropins in the treatment of female infertility a clinical trial



Cost effectiveness of gamete intrafallopian transfer in comparison with induction of ovulation with gonadotropins in the treatment of female infertility a clinical trial



Fertility & Sterility 57(1): 163-167



Objective: To compare the cost-effectiveness of gamete intrafallopian transfer (GIFT) with that of conventional infertility treatment in couples with female infertility, excluding tubal factors. Design: Patients were randomly divided in two groups: receiving GIFT or conventional infertility treatment. For a period of 2 years, GIFT was compared with conventional infertility treatment in couples with endometriosis, anovulation, idiopathic infertility, cervical mucus factor, female immunologic factor, or multifactorial causes of infertility in a randomized clinical trial. Setting: The study was performed in the Unit for Human Reproduction, Department of Obstetrics and Gynaecology, Faculty of Medicine, University of the Orange Free State, Bloemfontein, Republic of South Africa. Patients: One hundred seventy-four successive couples with female infertility were selected for the study. All couples were from the higher socioeconomic bracket. Interventions: One group received GIFT and the other received conventional infertility treatment consisting of infunction of ovulation with gonadotropins followed by intrauterine artificial insemination or normal intercourse. Main Outcome Measures: The results were stratified according to the specific cause of infertility. Outcome was measured by the success rate per treatment cycle, as well as the cost per pregnancy. Results: Overall, GIFT proved to be successful in 26.7% of treatment cycles compared with 9.7% with conventional therapy. Conclusions: After careful analysis, the authors came to the conclusion that GIFT is more cost-effective than conventional infertility treatment in patients with endometriosis and anovulation. In patients with idiopathic infertility, immunologic infertility, a cervical mucus factor, and multifactorial infertility, induction of ovulation followed by intrautrine artificial insemination or normal intercourse proved to be more cost-effective.

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Accession: 007165561

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PMID: 1730312


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