+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cost effectiveness of monitoring warfarin therapy using standard versus capillary prothrombin times

Cost effectiveness of monitoring warfarin therapy using standard versus capillary prothrombin times

American Journal of Clinical Pathology 91(5): 587-589

The authors assessed the cost effectiveness of monitoring warfarin therapy guided by standard plasma prothrombin times performed on blood samples obtained by venipuncture versus prothrombin times performed on capillary whole blood samples obtained by fingerstick. Twenty patients receiving long-term oral anticoagulation had either standard or capillary prothrombin times determined every other week for eight weeks in a cross-over design. All time intervals were monitored, including receptionist, secretarial, nursing, phlebotomy, etc., and costs for all materials, procedures, and labor were calculated. The total cost per test by the capillary whole blood prothrombin time method was significantly less than by standard prothrombin time methods ($7.55 vs. $15.64) even though the nurse-patient encounter time was greater per test for the capillary method (12.4 minutes vs. 8.3 minutes). The management of oral anticoagulation guided by prothrombin times performed on instrumentation designed to sample capillary whole blood should result in a significant cost savings, and because of the immediate availability of results, provide the potential for improved health care.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 007165565

Download citation: RISBibTeXText

PMID: 2497638

DOI: 10.1093/ajcp/91.5.587

Related references

Fiix-prothrombin time versus standard prothrombin time for monitoring of warfarin anticoagulation: a single centre, double-blind, randomised, non-inferiority trial. Lancet. Haematology 2(6): E231-E240, 2015

Fiix-prothrombin time monitoring improves warfarin anticoagulation outcome in atrial fibrillation: a systematic review of randomized trials comparing Fiix-warfarin or direct oral anticoagulants to standard PT-warfarin. International Journal of Laboratory Hematology 38(Suppl. 1): 78-90, 2016

Cost effectiveness of early versus late initiation of warfarin during heparin therapy. Pharmacotherapy 10(3): 246, 1990

Cost effectiveness of continued-warfarin versus heparin-bridging therapy during pacemaker and defibrillator surgery. Journal of the American College of Cardiology 65(9): 957-959, 2015

Warfarin therapy. The effect of heparin on prothrombin times. Archives of Internal Medicine 147(3): 432-433, 1987

Novel oral anticoagulants versus warfarin therapy at various levels of anticoagulation control in atrial fibrillation--a cost-effectiveness analysis. Journal of General Internal Medicine 29(3): 438-446, 2014

Cost-effectiveness analysis of adjunct VSL#3 therapy versus standard medical therapy in pediatric ulcerative colitis. Journal of Pediatric Gastroenterology and Nutrition 53(5): 489-496, 2011

Cost-effectiveness of dabigatran versus genotype-guided management of warfarin therapy for stroke prevention in patients with atrial fibrillation. Plos one 7(6): E39640, 2012

A Markov process analysis comparing the cost effectiveness of maintenance therapy with citalopram versus standard therapy in major depression. Pharmacoeconomics 8(2): 159-168, 1995

Cost-effectiveness comparison of sequential ofloxacin versus standard switch therapy. Annals of PharmacoTherapy 31(10): 1137-1145, 1997

Prothrombin complex concentrate versus standard therapies for INR reversal in trauma patients receiving warfarin. Annals of PharmacoTherapy 45(7-8): 869-875, 2011

Cost-effectiveness of early versus standard antiretroviral therapy in HIV-infected adults in Haiti. Plos Medicine 8(9): E1001095, 2011

Correlation of prothrombin times with factor II, IX and X activities in patients on warfarin therapy with and without lupus anticoagulants. Blood 90(10 Suppl. 1 Part 1): 469A, 1997

Comparative effectiveness of 3- versus 4-factor prothrombin complex concentrate for emergent warfarin reversal. Thrombosis Research 136(3): 595-598, 2015

Time to Cost-Effectiveness Following Stroke Reduction Strategies in AF: Warfarin Versus NOACs Versus LAA Closure. Journal of the American College of Cardiology 66(24): 2728-2739, 2015