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Cotinine in an ultrafiltrate of saliva



Cotinine in an ultrafiltrate of saliva



Preventive Medicine 21(1): 63-73



Background: We have developed a device for the simplified collection of a prepurified sample of saliva in the mouth. Methods: The device is based on the principle of an osmotic pump and accumulates about 1.2 ml of an ultrafiltrate of saliva within 8 min. We have investigated the ultrafiltrate for its utility as a biological medium in the evaluation of cigarette smoking status. Results: (a) In 58 matched samples from 13 subjects, the correlation coefficient for the cotinine concentration in the saliva and the ultrafiltrate was 0.95; (b) in matched plasma and ultrafiltrate samples from 27 smokers, the correlation coefficient for the cotinine concentrations was 0.96 with plasma containing 1.2 times the ultrafiltrate mean; (c) in a nonsmoker, elevated cotinine levels could be detected in the ultrafiltrate more than 24 hr after smoking 2 cigarettes, and the pattern of rise and decrease reflected that a whole saliva; and (d) in a habitual smoker, the mean cotinine concentration in the ultrafiltrate was 157 ng/ml (SD .+-. 25.7 ng/ml) during a period of smoking 15 cigarettes per day and dropped to a mean of 47 ng/ml (SD .+-. 10.5) when smoking was reduced to 5 cigarettes per day; after cessation of smoking, detectable concentrations of cotinine persisted for up to 5 days. Conclusion: The device facilitated the aesthetic, noninvasive collection of a biological sample useful in the validation of smoking status.

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Accession: 007165690

Download citation: RISBibTeXText

PMID: 1738769

DOI: 10.1016/0091-7435(92)90006-4


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