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Cotreatment with growth hormone for induction of spermatogenesis in patients with hypogonadotropic hypogonadism



Cotreatment with growth hormone for induction of spermatogenesis in patients with hypogonadotropic hypogonadism



Fertility and Sterility 57(5): 1044-1051



Objective: To induce spermatogenesis by cotreatment with growth hormone (GH) and gonadotropin therapy in patients with hypogonadotropic hypogonadism who had failed to respond adequately to conventional treatment. Design: Cotreatment with GH (4 IU) and human menopausal gonadotropin, 150 IU of follicle-stimulating hormone and 150 IU of luteinizing hormone (LH), three times a week, and human chorionic gonadotropin, 2,500 IU, two times a week for 24 weeks after unsuccessful treatment for 12 weeks with either pulsatile LH-releasing hormone or gonadotropins. Setting: Specialist Reproductive Endocrine Unit. Patients, Participants: Seven patients, four of whom had failed to respond adequately to the conventional treatment. Main Outcome Measures: Serum testosterone (T), estradiol, and sperm production, testicular and semen volume, and serum insulin-like growth factor-I and inhibin concentrations. Results: Of the four patients who received cotreatment with GH, three increased T secretion (<11 nmol/L) within a relatively short period of time, two produced adequate amount of sperm (13 and 12 .RTM. 106/mL), and one of them impregnated his wife. One patient did not respond. Conclusion: The results offer a new approach to the problem of induction of spermatogenesis in patients who respond poorly to conventional treatment because cotreatment with GH enhanced T secretion and sperm production in a relatively short period of time.

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Accession: 007165720

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PMID: 1572472


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