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Counteraction by nicardipine of the ionophoretic effect of gliclazide: a mitochondrial study



Counteraction by nicardipine of the ionophoretic effect of gliclazide: a mitochondrial study



Pharmacological Research 24(1): 33-40



Using mitochondria, we demonstrate that gliclazide exhibits a calcium ionophoretic activity. Indeed, gliclazide induces a decrease in the respiratory control of mitochondria; this effect is increased by addition of Ca2+ and corrected by ruthenium red, all characteristics of a calcium ionophoretic compound. Our results, on a biological membrane, confirm previous findings in vitro. Moreover, we show that nicardipine counteracts the action of gliclazide. Besides the effect on ATP-stimulated K+ channels, the ionophoretic effect of gliclazide may play a role in its hypoglycaemic effect, thus this counteracting action of nicardipine might induced drug interaction during the concomitant clinical administration of gliclazide and nicardipine.

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Accession: 007165911

Download citation: RISBibTeXText

PMID: 1719513

DOI: 10.1016/1043-6618(91)90062-3


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