+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Counteraction by nicardipine of the ionophoretic effect of gliclazide: a mitochondrial study

Counteraction by nicardipine of the ionophoretic effect of gliclazide: a mitochondrial study

Pharmacological Research 24(1): 33-40

Using mitochondria, we demonstrate that gliclazide exhibits a calcium ionophoretic activity. Indeed, gliclazide induces a decrease in the respiratory control of mitochondria; this effect is increased by addition of Ca2+ and corrected by ruthenium red, all characteristics of a calcium ionophoretic compound. Our results, on a biological membrane, confirm previous findings in vitro. Moreover, we show that nicardipine counteracts the action of gliclazide. Besides the effect on ATP-stimulated K+ channels, the ionophoretic effect of gliclazide may play a role in its hypoglycaemic effect, thus this counteracting action of nicardipine might induced drug interaction during the concomitant clinical administration of gliclazide and nicardipine.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 007165911

Download citation: RISBibTeXText

PMID: 1719513

DOI: 10.1016/1043-6618(91)90062-3

Related references

Calcium anti-ionophoretic effect of nicardipine and diltiazem Proton NMR and mitochondrial studies. Wegmann, R J , Wegmann, M A Recent Advances in Cellular and Molecular Biology, Vol 4 ; Molecular pathways of kinases, protein expression, blood pressure regulators, Ca-2 channels and molecular receptors : 183-189, 1992

Nicardipine hydrochloride injectable phase IV open-label clinical trial: study on the anti-hypertensive effect and safety of nicardipine for acute aortic dissection. Journal of International Medical Research 30(3): 337-345, 2002

Liquid chromatography--mass spectrometry method for the determination of gliclazide in human plasma and application to a pharmacokinetic study of gliclazide sustained release tablets. Arzneimittel-Forschung 58(12): 653-658, 2009

Sphingolipids and glycerolipids: IV. Syntheses and ionophoretic activities of several analogues of soya-cerebroside II, a calcium ionophoretic sphingoglycolipid isolated from soybean. Chemical & Pharmaceutical Bulletin 41(9): 1534-1544, 1993

An experimental, randomized, double-blind, placebo-controlled clinical trial to infestigate the effect of nicardipine on cognitive function in patients with vascular dementia. Spanish group of nicardipine study in vascular dementia. Revista de Neurologia 28(9): 835-845, 1999

Effect of pentobarbital on neurones in the reticular formation of the brain stem: ionophoretic study in the rat. General Physiology and Biophysics 3(6): 463-473, 1984

Forced Degradation Study on Gliclazide and Application of Validated Stability-Indicating HPLC-UV Method in Stability Testing of Gliclazide Tablets. Chromatographia 66(9-10): 751-755, 2007

Ionophoretic properties and mitochondrial effects of cereulide: the emetic toxin of B. cereus. European Journal of Biochemistry 263(1): 112-117, 1999

Efficacy and safety of intravenous nicardipine in the control of postoperative hypertension. IV Nicardipine Study Group. Chest 99(2): 393-398, 1991

Determination of (+)- and (-)-nicardipine concentrations in human serum and their correlation with the antihypertensive effect after oral administration of racemic nicardipine. European Journal of Clinical Pharmacology 48(5): 345-349, 1995

Bioequivalence study of nicardipine solution versus nicardipine tablets. Clinical and Experimental Hypertension 26(4): 375-386, 2004

Nicardipine in the treatment of essential hypertension controlled 6-month-study comparing nicardipine with propranolol at rest and during exercise. European Journal of Clinical Pharmacology 33(1): 15-20, 1987

Use of slow release nicardipine in the treatment of mild moderate arterial hypertension comparative clinical study with nicardipine and chlorthalidone. Archivio di Medicina Interna 42(3-4): 161-170, 1990

Micro ionophoretic study of the effect of serotonin on evoked electric activity of rabbit visual cortical neurons. Doklady Akademii Nauk SSSR Seriya Biologiya 212(1): 258-261, 1973

Mediation by 5-HT-3 receptors of an excitatory effect of 5-HT on dorsal vagal preganglionic neurones in anaesthetized rats: An ionophoretic study. British Journal of Pharmacology 118(7): 1697-1704, 1996