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Counteraction of nifedipine induced hyperglycemia by metformin

Counteraction of nifedipine induced hyperglycemia by metformin

Diabete & Metabolisme 16(6): 522-523

Nifedipine-induced hyperglycaemia in rats was counteracted by concurrent administration of metformin (500 mg/kg p.o.). However, glibenclamide (5 mg/kg p.o.) did not change the hyperglycaemic effect of nifedipine. It is suggested that nifedipine-induced hyperglycaemia was not related to pancreatic effect and might be attributed to extra pancreatic mechanism by preventing the action of insulin in the tissues. Therefore, counteraction of nifedipine-induced hyperglycaemia by metformin, may play a role in diabetic patients treated with nifedipine.

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Accession: 007165913

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PMID: 2128281

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