+ Site Statistics
References:
52,572,879
Abstracts:
28,705,754
PMIDs:
27,750,366
DOIs:
25,464,004
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Counterregulatory adaptation to recurrent hypoglycemia in normal humans



Counterregulatory adaptation to recurrent hypoglycemia in normal humans



Journal of Clinical Endocrinology and Metabolism 73(5): 995-1001



We evaluated the effect of antecedent hypoglycemia on glucose counterregulation during hypoglycemia in non-diabetic human subjects. In single hypoglycemia studies, glucose production [( 3H]3-glucose) and counterregulatory hormone concentrations were measured (after a 3.5-h baseline period of euglycemia) during 120 min of hypoglycemia (glucose clamped at 3.0 mmol/L). During the final 60 min of hypoglycemia, counterregulation resulted in significant increments in glucose production (12.88 +/- 0.83 mumol/kg.min), and plasma glucagon (IRG; 185 +/- 22 ng/L), GH (29.3 +/- 7.0 micrograms/L), cortisol (630 +/- 100 nmol/L), epinephrine (3.44 +/- 0.76 nmol/L), and norepinephrine (2.02 +/- 0.21 nmol/L). In the recurrent hypoglycemia experiment, an antecedent period of identical hypoglycemia was induced. Glucose counterregulation during the second of two periods of hypoglycemia (HYPO 2) was then compared to that in single hypoglycemia studies. During HYPO 2, there were decreased responses in Ra (by 32%; P less than 0.03), GH (by 67%; P less than 0.05), F (by 41%; P less than 0.03), and norepinephrine (by 20%; P = 0.03) compared to those in the single hypoglycemia study. In contrast, plasma IRG values were similar in the single hypoglycemia studies and HYPO 2, but were reduced relative to those during the first hypoglycemic period of recurrent hypoglycemia (IRG, 263 +/- 18 ng/L; P less than 0.025 vs. HYPO 2 and P less than 0.05 vs. single hypoglycemia). Our results suggest that 1) antecedent hypoglycemia may alter glucose counterregulation during hypoglycemia; and 2) recurrent hypoglycemia may result in alterations in reduction of hepatic glucose production.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 007165951

Download citation: RISBibTeXText

PMID: 1939537

DOI: 10.1210/jcem-73-5-995


Related references

Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans. Diabetes 49(11): 1897-1903, 2000

Gender-related differences in counterregulatory responses to antecedent hypoglycemia in normal humans. Journal of Clinical Endocrinology and Metabolism 85(6): 2148-2157, 2000

Effects of physiological hyperinsulinemia on counterregulatory response to prolonged hypoglycemia in normal humans. American Journal of Physiology 267(3 Pt 1): E402-E410, 1994

Hypoglycemia-associated autonomic failure in healthy humans: comparison of two vs three periods of hypoglycemia on hypoglycemia-induced counterregulatory and symptom response 5 days later. Journal of Clinical Endocrinology and Metabolism 99(2): 664-670, 2014

Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans. Diabetes 36(4): 518-522, 1987

Counterregulatory response to hypoglycemia differs according to the insulin delivery route, but does not affect glucose production in normal humans. Journal of Clinical Endocrinology and Metabolism 84(3): 1037-1046, 1999

Effect of hyperketonemia and hyperlacticacinemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans. Diabetes 43(11): 1311-1317, 1994

Effect of Hyperketonemia and Hyperlacticacidemia on Symptoms, Cognitive Dysfunction, and Counterregulatory Hormone Responses During Hypoglycemia in Normal Humans. Diabetes 43(11): 1311-1317, 1994

Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure. Diabetes 57(2): 470-475, 2007

Fructose amplifies counterregulatory responses to hypoglycemia in humans. Diabetes 51(4): 893-900, 2002

Metformin has no adverse effects on counterregulatory responses to recurrent hypoglycemia. Experimental & Clinical Endocrinology & Diabetes 109(Suppl 1): S50, 2001

Further defects in counterregulatory responses induced by recurrent hypoglycemia in IDDM. Diabetes 41(10): 1335-1340, 1992

Effect of physiological hyperinsulinemia on counterregulatory hormone responses during hypoglycemia in humans. Journal of Clinical Endocrinology and Metabolism 75(5): 1293-1297, 1992

Counterregulatory response to insulin-induced hypoglycemia in trained and nontrained humans. Metabolism: Clinical and Experimental 39(11): 1138-1143, 1990

Effect of bilateral carotid body resection on the counterregulatory response to hypoglycemia in humans. Experimental Physiology: -, 2014