Cytogenetic effect of natural mutagenesis modifiers in the culture of human lymphocytes modification of the mutagenic effect by recombinant interferon in vitro in lymphocytes of patients with bronchial asthma and in healthy donors
Movsesyan, E.S.; Sarkisyan, T.F.; Arutyunyan, R.M.
Tsitologiya i Genetika 24(2): 21-24
The significant protective effect of recombinant interferon in the cultures of lymphocytes of healthy donors and patients with bronchial asthma has been revealed. The cytogenetic damage were stimulated by alkylating agents thioTEPA and photrin during their administration at the stages Gi-S of the cell cycle. No differences were revealed in the action of mutagens and protector in the patients and healthy persons.