+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Delta infection in asymptomatic carriers of hepatitis B surface antigen: low prevalence of delta activity and effective suppression of hepatitis B virus replication



Delta infection in asymptomatic carriers of hepatitis B surface antigen: low prevalence of delta activity and effective suppression of hepatitis B virus replication



Hepatology 8(5): 1121-1124



We examined the prevalence of serum anti-.delta. antibody among 769 intravenous drug abusers in Taiwan. .delta. infection was found extremely common in the HBsAg-positive carriers with drug abuse, because 128 (85%) of 151 carriers were positive for anti-.delta. However, most of antibody titers were low (< 1:5,000). By molecular hybridization, .delta. RNA genomes were detectable in only five (4%) of 128 asymptomatic carriers positive for anti-.delta. The results suggest that most of them had previous, instead of ongoing, .delta. infection. We also studied the serum markers reflecting hepatitis B virus replication in these carriers and a control group. Hepatitis B e antigen was positive in only 12 (10%) of 115 anti-.delta. positive carriers in contrast to 22 (23%) of 95 age- and sex-matched HBsAg-positive, anti-.delta. negative volunteers donating blood (p < 0.025). Furthermore, in contrast to the close association between HBeAg and hepatitis B virus DNA generally present in HBsAg carriers (concordance in this series: 79%), among the 12 HBeAg-positive subjects of the .delta. infected group, only two, or 17%, had serum hepatitis B virus DNA (p < 0.003). Such suppressing effects did not require a simultaneous presence of the .delta. agent, as shown by the lack of .delta. RNA genomes in the serum by sensitive assay. We conclude that although .delta. superinfection is common in the asymptomatic HBsAg carriers with intravenous drug abuse in the nonendemic area of Taiwan, continuous .delta. activities are uncommon in them. In addition, the previous .delta. infection probably exerts effective suppression on the hepatitis B virus replication in these HBsAg carriers.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 007182951

Download citation: RISBibTeXText

PMID: 3417233


Related references

Prevalence of infection with hepatitis delta virus (HDV) among carriers of hepatitis B surface antigen in Amazonas State, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene 82(3): 469-471, 1988

Hepatitis delta virus antibodies in hepatitis B surface antigen asymptomatic carriers in Senegal. Journal of Infectious Diseases 161(1): 150-151, 1990

Clinical significance of antibody against the hepatitis delta virus in asymptomatic hepatitis b surface antigen carriers. Journal of Hepatology (Suppl. 2): S184, 1985

Liver disease activity and hepatitis B virus replication in chronic delta antigen-positive hepatitis B virus carriers. Hepatology 5(4): 544-547, 1985

Elimination of Hepatitis Delta Virus Infection After Loss of Hepatitis B Surface Antigen in Patients With Chronic Delta Hepatitis. Journal Of Medical Virology. 44(4): 389-392, 1994

Delta-infection and suppression of hepatitis B virus replication in chronic HBsAg carriers. Hepatology 7(1): 42-45, 1987

RNA-binding activity of hepatitis delta antigen involves two arginine-rich motifs and is required for hepatitis delta virus RNA replication. Journal of Virology 67(4): 2221-2227, 1993

Chronic delta hepatitis detection of hepatitis delta virus antigen in serum by immunoblot and correlation with other markers of delta viral replication. Hepatology 10(6): 907-910, 1989

Prevalence of delta antigen and anti delta by radio immunoassay among various groups of hepatitis b surface antigen carriers in france. Verme, G , F Bonino And M Rizzetto (Ed ) Progress in Clinical And Biological Research, Vol 143 Viral Hepatitis And Delta Infection; International Symposium, Torino, Italy, June 10-11, 1983 Xxii+421p Alan R Liss, Inc : New York, N Y , Usa Illus P287-288, 1984

Prevalence of hepatitis b e antigen antibody to hepatitis b e antigen and dane particle associated dna polymerase activity in asymptomatic carriers of hepatitis b surface antigen. Ricerca in Clinica e in Laboratorio 9(1): 35-40, 1979

Prevalence of hepatitis delta virus infection among hepatitis B virus surface antigen positive patients circulating in the largest province of Pakistan. Virology Journal 7: 283, 2010

Hepatitis B x antigen and polymerase antibodies in the serum of hepatitis B carriers with or without hepatitis delta virus infection. Journal of Hepatology 14(2): 286-293, 1992

Hepatitis B x antigen and polymerase antibodies in the serum of hepatitis B carriers with or without hepatitis delta virus infection. Effects of interferon treatment. Journal of Hepatology 14(2-3): 286-293, 1992

Suppression of hepatitis b virus replication in chronic hbsag carriers superinfected with hepatitis delta virus. Hepatology 7(5): 1145, 1987

Prevalence of delta hepatitis virus among asymptomatic HBs antigen + blood donors and in HBs antigen + hepatitis in Mauritania. Gastroenterologie Clinique et Biologique 18(2): 176, 1994