+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Different hematologic responses to hypoxia in Sherpas and Quechua Indians

Different hematologic responses to hypoxia in Sherpas and Quechua Indians

Journal of Applied Physiology 66(4): 1561-1569

Previous studies of the erythropoietic response to hypoxia in high-altitude natives suggest that the hematocrit and hemoglobin values in Himalayan natives (Sherpas) are lower than expected for the altitude, perhaps because of a genetic adaptation. However, differences in sampling techniques and experimental methods make comparisons difficult. Our studies were carried out to compare the erythropoietic response with the same altitude in age-matched natives of the Himalayas and Andes by the same experimental techniques. Healthy male subjects were selected in Ollagüe, Chile (n = 29, 27.3 +/- 5.9 yr) and in Khunde, Nepal (n = 30, 24.7 +/- 3.8 yr). Both of these villages are located at 3,700 m above sea level. Hematologic measurements confirmed lower hematocrit values in Nepal (48.4 +/- 4.5%) than in Chile (52.2 +/- 4.6%) (P less than 0.003). When subjects were matched for hematocrit, erythropoietin concentrations in Chile were higher than in Nepal (P less than 0.01). Detailed measurements of blood O2 affinity in Nepal showed no differences in shape or position of the O2 equilibrium curve between Sherpas and Western sojourners. Our results indicate that although Quechua Indians have higher hematocrits than Sherpas living at the same altitude, nevertheless they may be functionally anemic.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 007207730

Download citation: RISBibTeXText

PMID: 2732148

DOI: 10.1152/jappl.1989.66.4.1561

Related references

Hematologic response to hypoxia in sherpas and quechua indians. FASEB Journal 2(6): ABSTRACT 8277, 1988

Responses of Quechua Indians to coca ingestion during cold exposure. American Journal of Physical Anthropology 34(2): 273-277, 1971

Observations on the dentition of the northern indians and the northeast sherpas. Aichi-Gakuin Journal of Dental Science 19(3): 84-107, 1981

Respiratory function in peruvian quechua indians. Annals of Human Biology 1(2): 137-148, 1974

Morphology and total body cooling among quechua indians. American Journal of Physical Anthropology 33(1): 146, 1970

The technology of self-respect: cultural projects among Aymara and Quechua Indians. Grassroots development(1): 32-37, 1982

Medicinal herbs of the Quechua Indians of Napo Province, Ecuador. 1987

Diet of Quechua Indians Living at High Altitude: Nu Noa, Peru. American Journal of Clinical Nutrition 15: 341-351, 1964

Skin reflectance of Quechua indians: the effects of genetic admixture, sex and age. American Journal of Physical Anthropology 36(2): 267-281, 1972

Diet and physical characteristics of quechua indians from 3 peruvian highland communities. American Journal of Physical Anthropology 33(1): 131, 1970

Cold stress and micro climate in the quechua indians of southern peru. Dissertation Abstracts B Sciences & Engineering 29(9): 3172-B, 1969

Origin of Bolivian Quechua Amerindians Their relatedness with other American Indians and Asians. Genes & Immunity 5(Suppl 1): S56, 2004