EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Differentiation between extrahepatic and intrahepatic cholestasis by discriminant analysis



Differentiation between extrahepatic and intrahepatic cholestasis by discriminant analysis



Journal of Paediatrics & Child Health 26(3): 132-135



Discriminant analysis was used to differentiate between extrahepatic biliary atresia and intrahepatic cholestatis. Among the ten laboratory variables tested, three (.gamma.-glutamyl transpeptidase, alkaline phosphatase and total serum bilirubin) were useful in the differential diagnosis. .gamma.-Glutamyl transpeptidase contributed most to the discrimination (85%). From a population study of 28 babies with extrahepatic biliary atresia and 24 infants with intrahepatic cholestasis, the procedure achieved a diagnostic accuracy and specificity of 92.9% and an efficiency of 92.3%. The jackknife procedure has also confirmed that the mathematical model was robust for discriminant analysis and therefore it may be valid for screening infants with cholestasis for early surgical intervention. Discriminant analysis is a useful adjunct for differentiation between intrahepatic cholestasis and extrahepatic biliary atresia.

Accession: 007211888

Download citation: RISBibTeXText

PMID: 1976325

DOI: 10.1111/j.1440-1754.1990.tb02409.x

Download PDF Full Text: Differentiation between extrahepatic and intrahepatic cholestasis by discriminant analysis



Related references

Cholestasis in alcoholic chronic pancreatitis diagnostic value of the transaminase ratio for differentiation between extrahepatic and intrahepatic cholestasis. Scandinavian Journal of Gastroenterology 20(7): 851-856, 1985

Extrahepatic cholestasis in the dog and the differentiation of extrahepatic and intrahepatic cholestasis. Veterinary Quarterly 8(2): 150-157, 1986

Statistical evaluation of biochemical data by the method of discrimination analysis. Selection of the discriminant biochemical variables. Attempted biochemical discrimination of intrahepatic cholestasis, extrahepatic obstruction and liver cancer. Annales de Biologie Clinique 33(6): 411-422, 1975

Diagnosis of extrahepatic obstructive jaundice with ultrasonic tomography, with special reference to differentiation from intrahepatic cholestasis. Nihon Shokakibyo Gakkai Zasshi 73(11): 1389-1400, 1976

NR1H4 analysis in patients with progressive familial intrahepatic cholestasis, drug-induced cholestasis or intrahepatic cholestasis of pregnancy unrelated to ATP8B1, ABCB11 and ABCB4 mutations. Clinics and Research in Hepatology and Gastroenterology 36(6): 569-573, 2013

Quantitative determination of lipoprotein-X (LP-X) in extrahepatic cholestasis and intrahepatic cholestasis. Revista Medica de Chile 112(3): 233-237, 1984

Possibilities and limits of ultrasonic tomography in extrahepatic cholestasis. I: Differential diagnosis of extra from intrahepatic-induced cholestasis. Zeitschrift für Arztliche Fortbildung 79(13): 559-561, 1985

Cholestasis and hepatic drug metabolism. Comparison of metabolic clearance rate of antipyrine in patients with intrahepatic or extrahepatic cholestasis. Digestive Diseases and Sciences 26(8): 718-722, 1981

Benign recurrent intrahepatic cholestasis progressing to progressive familial intrahepatic cholestasis: Low GGT cholestasis is a clinical continuum. Journal of Hepatology 36(3): 439-443, March, 2002

Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy. Best Practice & Research. Clinical Gastroenterology 24(5): 541-553, 2011

Lipoprotein-X levels in extrahepatic versus intrahepatic cholestasis. Gastroenterology 75(2): 177-180, 1978

Morphologic findings in the liver in intrahepatic and extrahepatic cholestasis. Deutsche Zeitschrift für Verdauungs- und Stoffwechselkrankheiten 25(4): 151-154, 1965

Ultrasound in differential diagnosis of intrahepatic and extrahepatic cholestasis. Deutsche Medizinische Wochenschrift 103(42): 1643-1647, 1978

A molecular basis for jaundice in intrahepatic and extrahepatic cholestasis. Hepatology 26(6): 1682-1684, 1997