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Digoxin therapy in infants with heart failure ii. dose response relationship between serum digoxin concentration and left ventricular performance



Digoxin therapy in infants with heart failure ii. dose response relationship between serum digoxin concentration and left ventricular performance



Tokyo Jikeikai Medical Journal 105(2): 345-354



Beta-methyldigoxin and digoxin were administered orally to 29 infants with congestive heart failure, and changes in the left ventricular performance after the administration were evaluated by M-mode echocardiography. After the administration of digoxin, LVEF and mVcf increased significantly, and LVPEP/LVET decreased significantly. Changes in LVEF and mVcf became significant only when the serum digoxin level was elevated up to 0.7 ng/ml or more. Among the two values, mVcf showed the highest percent change when the serum digoxin level was 1.0 .apprx. 1.2 ng/ml and no further significant change at the serum level higher than 1.2 ng/ml. Changes in LVPEP/LVET became significant only when the serum digoxin level was elevated up to 1.0 ng/ml or more. These results suggest that, in the oral digoxin or .beta.-methyldigoxin treatment of heart failure in infants, the optimal serum digoxin concentration may be 1.0 .apprx. 1.2 ng/ml.

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Accession: 007213367

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