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Direct action of bromocriptine on the production of progesterone and estradiol 17 beta by the human corpus luteum



Direct action of bromocriptine on the production of progesterone and estradiol 17 beta by the human corpus luteum



Japanese Journal of Fertility & Sterility 34(4): 44-48



To confirm the usefulness of bromocriptine (Br) in cases of inadequate luteal phase with normoprolactinemia, monolayer cell cultures of human corpora lutea of menstrual cycle were created and experiments with Br added to the culture medium were carried out. Progesterone (P) was increased significantly by 1 and 10 ng/ml of Br. The effects of Br were stronger at a dose of 1 ng/ml on the corpus luteum in a low P production group than in a high p production group. The production of estradiol-17.beta. was not significantly different after the addition of Br. These results indicate that Br increased P production by direct stimulation of the corpus luteum, and that the administration of Br is useful in the treatment of an inadequate luteal phase.

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