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Dissemination in five french hospitals of klebsiella pneumoniae serotype k25 harboring a new transferable enzymatic resistance to third generation cephalosporins and aztreonam



Dissemination in five french hospitals of klebsiella pneumoniae serotype k25 harboring a new transferable enzymatic resistance to third generation cephalosporins and aztreonam



European Journal of Clinical Microbiology & Infectious Diseases 7(6): 780-782



A strain of Klebsiella pneumoniae K25 resistant to newer .beta.-lactam drugs was isolated in clusters in five hospitals in the Paris area. The MICs of ceftazidime and aztreonam (.gtoreq. 128 mg/l) were higher than that of cefotaxime (16 mg/l) for the strain but, when measured in the presence of clavulanic acid, they were LEQ 1 mg/l. The donor strains and derivatives produced a .beta.-lactamase with a pI of 7.75.sbd.7.8 and hydrolysing activity against a wide spectrum of .beta.-lactams similar to that of SHV-2 and SHV-3, but with significant hydrolysis of ceftazidime. This new enzyme oculd be designated SHV-4.

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Accession: 007218008

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PMID: 3145863



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