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Dissociation of cimetidine effects on inotropic and chronotropic action in cardiac anaphylaxis



Dissociation of cimetidine effects on inotropic and chronotropic action in cardiac anaphylaxis



Zhongguo Yao Li Xue Bao 10(2): 140-143



The changes of heart rate (HR) and dP/dtmax elicited by challenging the sensitized heart and by a bolus injection of histamine in the presence of cimetidine were observed. The results showed that cimetidine did not completely inhibit the positive chronotropic effect in cardiac anaphylaxis. The increase in HR elicited by exogenous histamine on sensitized heart was completely abolished. Cimetidine inhibited the positive inotropic and chronotropic effect of histamine on normal heart in a dose-dependent manner. It is suggested either an H2 receptor subtype or concomitant with the release of histamine, other mediators eliciting positive chronotropism in cardiac anaphylaxis may exist,.affected(2). In order to investigate the mechanism of the dissociation of the inhibitory effect of cimetidine on the positive inotropic and chronotropic action, we observed the changes in HR and dP/dtmax which occurred in phase I of cardiac anaphylaxis in the presence of different concentrations of cimetidine, and compared them with the effects of exogenous histamine. The dose-response relationship between HR and dP/dtmax for histamine at various concentrations of cimetidine was also studied.

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Accession: 007218234

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PMID: 2816414



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