+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Distinct antigen expression related to DNA ploidy in a case of biphenotypic leukemia

Distinct antigen expression related to DNA ploidy in a case of biphenotypic leukemia

Leukemia 3(1): 76-78

Three cell populations with different DNA indices were demonstrated in a case of biphenotypic terminal transferase (TdT) myeloid-positive acute leukemia which had developed from a pre-leukemic diploid population also expressing biphenotypic features. At the time of development of acute leukemia, flow-cytometric analysis revealed expression of TdT by the diploid, the tetraploid, and the near-triploid cells, but only the tetraploid cells carried the myeloid-specific M2 antigen. Cytogenetic analysis showed four stemlines, diploid, tetraploid, tetraploid with del(2), and near-triploid with del(2) and variable chromosome losses. In vitro treatment with retinoic acid induced the expression of the M2 antigen by the diploid cells as well. This in vitro result is consistent with a myeloid differentiation commitment of the pluripotent leukemic stem cell.

(PDF emailed within 1 workday: $29.90)

Accession: 007218719

Download citation: RISBibTeXText

PMID: 2909810

Related references

Ineffective expression of molecules for antigen processing of HLA class I molecules on leukemia cells from biphenotypic leukemia. Blood 88(10 SUPPL 1 PART 1-2): 170B, 1996

Significance of Surface and Cytoplasmic Antigen Expression, Cytomorphology and Cytogenetics for Adequate Assignment of Biphenotypic Acute Leukemia A Validation Study Based on Gene Expression Profiles. Blood 100(11): Abstract No 4303, November 16, 2002

Biphenotypic expression in a case of acute leukemia with pericentric inv(6)(p12q24). Cancer Genetics and Cytogenetics 159(2): 187-189, 2005

Combined fibrolamellar carcinoma and cholangiocarcinoma exhibiting biphenotypic antigen expression: a case report. Journal of Clinical Pathology 58(8): 884-887, 2005

Categories based on KOR-SA3544 expression and ploidy have distinct molecular-genetic features that are relevant for prognosis in pediatric acute lymphoblastic leukemia. Blood 92(10 SUPPL 1 PART 1-2): 395A, Nov 15, 1998

CytCD79a expression in acute leukemia with t(8;21): biphenotypic or myeloid leukemia?. Cancer Genetics and Cytogenetics 174(1): 76-77, 2007

Biphenotypic leukemia a case of mixed t lymphoblastic and myeloblastic leukemia. Journal of Clinical Pathology (London) 38(5): 575-581, 1985

Clinical and biological characteristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leukemia: a case series of a Chinese population. Haematologica 94(7): 919-927, 2009

A case of acute biphenotypic leukemia. Japanese Journal of Clinical Hematology 28(5): 743-747, 1987

Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. Turkish Journal of Haematology 24(2): 85-87, 2007

Clinical course in a unique case of biphenotypic leukemia. Blood 94(10 SUPPL 1 PART 2): 217b, Nov 15, 1999

Biphenotypic acute leukemia: a case report. Journal of Biological Regulators and Homeostatic Agents 18(3-4): 387-391, 2005

Trisomy 4 in a case of acute biphenotypic leukemia. Cancer Genetics & Cytogenetics 47(2): 265-270, 1990

Biphenotypic acute leukemia: A case report. Journal of Biological Regulators and Homeostatic Agents 18(3-4): 387-391, 2004

Biphenotypic extramedullary blast crisis with MLL gene rearrangement in a case of chronic myeloid leukemia following Dasatinib therapy: An unusual case. Indian Journal of Pathology & Microbiology 59(2): 259-260, 2016