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Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity



Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity



Journal of Experimental Medicine 168(6): 2361-2366



Using a panel of antibodies specific for H and L chain variable region subgroups, a panel of human monoclonal cold agglutinin (CA) and rheumatoid factor (RF) autoantibodies were analyzed. The vast majority of the two types of autoantibodies utilized VkIII L chains, many of which probably derive from the Humkv325 gene. However, while most RFs (77%) utilized VHI H chains, all the CAs used VHII subgroup H chains. These results are consistent with a model of autoantibody generation, wherein binding specificity is H chain defined in a set of antibodies that use a multipotential L chain.

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Accession: 007218871

Download citation: RISBibTeXText

PMID: 3143801

DOI: 10.1084/jem.168.6.2361



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