Distribution of polyhexyl 2 cyano 2 carbon 14 acrylate nanoparticles in healthy and chronically inflamed rabbit eyes
Diepold, R.; Kreuter, J.; Guggenbuhl, P.; Robinson, J.R.
International Journal of Pharmaceutics 54(2): 149-154
ISSN/ISBN: 0378-5173 Accession: 007221518
The distribution of poly-hexyl-2-cyanoacrylate nanoparticles in aqueous humor, cornea, conjunctiva and nictitating membrane of albino rabbits in healthy and chronically inflamed eyes was studied using radiotracer techniques. Results indicate that the nanoparticles adhere to these tissues for several hours after instillation. The residence time in inflamed tissues was about 4 times higher than in healthy tissues. The low radioactivity observed in the aqueous humor was presumably due to degradation of the nanoparticles rather than to endocytosis of the intact nanoparticles.