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Does acute pancreatitis progress to chronic pancreatitis? a new chronic pancreatitis model in rats treated with repeated administration of caerulein



Does acute pancreatitis progress to chronic pancreatitis? a new chronic pancreatitis model in rats treated with repeated administration of caerulein



Tokyo Jikeikai Medical Journal 107(1): 1-16



The aim of this study is to elucidate the relationship between acute and chronic pancreatitis. The histological and biochemical alterations of the pancreas subjected to repeated administration of caerulein, an analogue of cholecystokinin, were studied in rats. Four consecutive subcutaneous injections of 15 .mu.g/kg body weight of caerulein at intervals of one hour induced acute edematous pancreatitis in the rats. The same treatment was given once a week for 44 weeks. Histological examination (light and electron micrographs) biochemical examination (serum enzyme, protein and enzyme content, test meal combined pancreatic functional diagnostant: TMC-PFD) were performed 45 weeks after starting the experiment. These parameters were re-examined further in rats treated with repeated administration of caerulein to evaluate the effects of choline-deficient low-protein diet. The following results were obtained: (1) Long term repeated administration of caerulein caused chronic pancreatitis. Acute pancreatitis progresses to chronic pancreatitis. (2) Histological changes were parenchymal atrophy and degenerative changes, cellular infiltration, intra- and inter-lobular fibrosis, ductular proliferation, and fat replacement. These changes were compatible with chronic pancreatitis. (3) Urinary excretion of PABA for functional test in TMC-PFD, serum enzyme, and protein and enzyme content were significantly decreased in the repeated caerulein administration groups in comparison with the control group. (4) In rats fed with choline-deficient low-protien diet, pancreatic injury was mild, and deficient of nutrition protected for pancreas. This is a new chronic pancreatitis model. It is very important to observe the time course of this model to elucidate the relationship between acute and chronic pancreatitis. Furthermore, this is a useful model for the study of the risk factor in chronic pancreatitis.

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