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Double blind placebo controlled food challenges dbpcfc demonstrating acute ige mediated allergic reactions to good start ultrafiltered good start alfare nutramigen and alimentum in a seven year old


Double blind placebo controlled food challenges dbpcfc demonstrating acute ige mediated allergic reactions to good start ultrafiltered good start alfare nutramigen and alimentum in a seven year old



Pediatric Asthma Allergy and Immunology 5(3): 245-252



A 7-year-old girl with IgE-mediated cows' milk allergy (immediate reactor) underwent double-blind, placebo-controlled food challenge (DBPCFC) with three whey hydrolysate formulas (Good Start, Ultrafiltered Good Start, Alfare) and two casein hydrolysates (Nutramigen, Alimentum), using a soy protein formula (Isomil) as a control. She developed acute reactions to Good Start (3 ml; gastrointestinal, respiratory), Ultra Good Start (8 ml; respiratory, cutaneous), Alfare (158 ml; respiratory), Nutramigen (3 ml; respiratory, cutaneous), and Alimentum (4 ml; respiratory, cutaneous, gastrointestinal) and tolerated the Isomil control (318 ml) on three separate challenges under similar conditions. The generalized urticarial reactions to Nutramigen and Alimentum began 90 minutes after receiving less than 1 teaspoonful (3 ml and 4 ml, respectively) of formula. These observations indicate that all current commercially available cow's milk protein hydrolysate formulas can cause serious allergic reactions in the highly sensitized cows' milk-allergic child. To our knowledge, this is the first report of an acute allergic reaction to Alimentum, which is currently marketed as hypoallergenic. Although many less sensitive cows' milk-allergic children can tolerate these formulas, the authors believe that the term "hypoallergenic" can create a false sense of security.

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Double-blind, placebo-controlled food challenges (DBPCFC) demonstrating acute IgE-mediated allergic reactions to Good Start, Ultrafiltered Good Start, Alfaré, Nutramigen, and Alimentum in a seven-year-old. Pediatric Asthma, Allergy and Immunology 5(3): 245-251, 1991

Double-Blind, Placebo-Controlled Food Challenges (DBPCFC) Demonstrating Acute IgE-Mediated Allergic Reactions to Good Start, Ultrafiltered Good Start, Alfar, Nutramigen, and Alimentum in a Seven-Year-Old. Pediatric Asthma Allergy and Immunology 5(3): 245-251, 1991

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