EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Effect of fish oil on atherogenesis in Watanabe heritable hyperlipidemic rabbit


Effect of fish oil on atherogenesis in Watanabe heritable hyperlipidemic rabbit



Arteriosclerosis 10(4): 597-606



ISSN/ISBN: 0276-5047

PMID: 2369369

DOI: 10.1161/01.atv.10.4.597

The effect of dietary supplementation with fish oil was investigated in the Watanabe heritable hyperlipidemic (WHHL) rabbit. Rabbits were fed Maxepa (1 g/kg body weight) from weaning for a 6-month period and were compared to controls. Fish oil supplements resulted in significant decreases in plasma triglyceride and cholesterol at 4 weeks after the start of the study, and these differences persisted over the 6-month period. No differences in the distribution of cholesterol or triglyceride among lipoprotein particles were found, nor were there differences in low density lipoprotein particle size. The decreases in plasma cholesterol and triglyceride were accompanied by significant increases in the percent of eicosapentaenoic and docosahexaenoic acids in both plasma and platelets. Fish oil supplementation resulted in a decrease in platelet count and response to the aggregating agents adenosine diphosphate, arachidonic acid, and collagen. Systolic blood pressure was significantly lower in the rabbits fed fish oil. At the end of the study period, aortic free and esterified cholesterol and intimal surface area covered with plaque were determined in the arch and in the descending and abdominal aorta. Significantly less cholesterol was found in the descending and abdominal aorta These diffferences were mirrored by decreased activities of acid lipase and N-acetyl-.beta.-glucosaminidase. In contrast, no differences in the intimal surface area covered with plaque were found. In conclusion, dietary fish oil resulted in a decrease in aortic lipid deposition in the WHHL rabbit, which may have been due to decreases in plasma triglyceride and cholesterol, platelet count and aggregability, and systolic blood pressure.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 007247724

Download citation: RISBibTeXText

Related references

The effect of propranolol on atherogenesis in the watanabe heritable hyperlipidemic rabbit whhl. Arteriosclerosis 8(5): 625A, 1988

Effets de l'héparine sur l'athérogenèse du lapin atteint de l'hyperlipidémie héréditaire de Watanabe - The effects of heparin upon atherogenesis in the Watanabe heritable hyperlipidemic rabbit. Annales de Chirurgie Vasculaire 4(4): 344-350, 1990

The effects of heparin upon atherogenesis in the Watanabe heritable hyperlipidemic rabbit. Annals of Vascular Surgery 4(4): 344-9; discussion 349-50, 1990

Effects of heparin upon atherogenesis in the watanabe heritable hyperlipidemic whhl rabbit. FASEB Journal 3(4): A1217, 1989

Probucol prevents atherogenesis in vivo in watanabe heritable hyperlipidemic rabbit an animal model for familial hypercholesterolemia. Circulation 76(4 Part 2): IV-294, 1987

The effect of dietary fish oil upon plasma lipoproteins and platelet function in the watanabe heritable hyperlipidemic rabbit whhl. FASEB Journal 2(4): Abstract 753, 1988

Fish oil feeding inhibits aortic atherogenesis in the watanabe hereditable hyperlipidemic rabbit whhl. Circulation 78(4 Part 2): II573, 1988

Atherogenesis in growing watanabe heritable hyperlipidemic whhl rabbits. Journal of Cellular Biochemistry Suppl (16 Part A): 28, 1992

The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe. Atherosclerosis 207(1): 1-7, 2009

Antiatherogenic effect of captopril in the watanabe heritable hyperlipidemic rabbit. Hypertension (Dallas, Tex 1979) 15(3): 327-331, 1990

Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit. Hypertension 15(3): 327-331, 1990

Heme oxygenase-1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits. Circulation 104(15): 1831-1836, 2001

Effects of omega 3 fatty acids on atherogenesis in watanabe heritable hyperlipidemic whhl rabbits. Federation Proceedings 46(3): 1006, 1987

Effect of behavioral interventions on insulin sensitivity and atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Psychosomatic Medicine 67(2): 172-178, 2005

Effect of probucol pb treatment on lipid composition in several tissues of watanabe heritable hyperlipidemic whhl rabbit. Japanese Circulation Journal 53(8): 899, 1989