Effect of h 1 and h 2 histamine receptor blocking agents on lesions of the gastric mucosa in guinea pigs induced by endogenous histamine
Patologicheskaya Fiziologiya i Eksperimental'naya Terapiya 5: 43-45
It was demonstrated in experiments on guinea pigs with the use of a histamine model of ulcerogenesis that blocking agents of H1-histamine receptors produced a more marked gastroprotective effect than H2-antagonists. The results of the study confirm the hypothesis that histamine-induced ulceration of the gastric mucosa occurs through the mediation of H1-receptors. H2-histamine receptors play a secondary role in this process.