Section 8
Chapter 7,250

Effect of h 1 and h 2 histamine receptor blocking agents on lesions of the gastric mucosa in guinea pigs induced by endogenous histamine

Karevina, T.G.

Patologicheskaya Fiziologiya i Eksperimental'naya Terapiya 5: 43-45


Accession: 007249010

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It was demonstrated in experiments on guinea pigs with the use of a histamine model of ulcerogenesis that blocking agents of H1-histamine receptors produced a more marked gastroprotective effect than H2-antagonists. The results of the study confirm the hypothesis that histamine-induced ulceration of the gastric mucosa occurs through the mediation of H1-receptors. H2-histamine receptors play a secondary role in this process.

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