Effect of high density lipoproteins on permeability of rabbit aorta to low density lipoproteins and acetylated low density lipoproteins
Zhou, Z.; Zhang, H.
Acta Academiae Medicinae Hubei 11(4): 294-297
A study was made on the effect of rabbits to LDL and acetylated LDL after intravenous administration of large dose of human HDL and 131LDL to normal and hypercholesterolemia rabbits, large dose of human HDL and 131AcLDL to normal rabbits. Radioactivity of plasma in the experimental rabbits of all groups is higher than that in the Control rabbits. Permeability rate of labelled lipoproteins in aorta of the control rabbits is hypercholesterolemia group > AcLDL group > LDL group. HDL decreased the permeability rate in aorta for 131LDL on an average by 18.668% in normal rabbits, by 48.280% in hypercholesterolemia rabbits, and for 131AcLDL on an average by 63.322% in normal rabbits. A historadiographic study also showed that HDL decreased the permeability of aorta wall to 131LDL in normal rabbits and particular in hypercholesterolemia rabbits, to 131AcLDL in normal rabbits. Permeability of labelled lipoproteins in the arch, thoracic and abdominal segments of aorta in the experimental rabbits is lower than that in the control rabbits. Inhibition of HDL on permeability of abdominal segment of aorta to labelled lipoproteins is greater than that of arch and thoracic segment. The above data suggested that AcLDL receptor is presented on the surface of endothelium of aorta, when HDL at very high molar concentration can hamper the transportation of LDL and AcLDL through the intact endothelium layer into the intima.