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Effect of loading conditions on peak aortic flow velocity and its maximal acceleration

Effect of loading conditions on peak aortic flow velocity and its maximal acceleration

Proceedings of the National Science Council, Republic of China. Part B, Life Sciences 15(3): 165-170

Aortic flow measurements with Doppler echocardiography has become a non-invasive technique in clinical practice. In the present animal study, we evaluated the flow-derived parameters such as peak velocity (PV) and its maximal acceleration (MA) as indices of ventricular contractility independent of the loading status. Eight pentobarbital-anesthetized cats were maintained with artificial ventilation. The chest was opened to place an electromagnetic flow probe around the ascending aorta for recording pulsatile aortic flow. PV and MA were measured from the flow tracing and on-line electronic differentiation. Intravenous infusions of dobutamine (DT), angiotensin II (AII) and dextran (DN) were used to alter the cardiac inotropism, afterload and preload, respectively. At a steady state (approximately 5 min after infusion), DT increased the PV from 56 .+-. 9 to 78 .+-. 14 cm/sec (p < 0.05) and MA from 1302 .+-. 108 to 1699 .+-. 117 cm/sec2 (p < 0.05). In response to AII infusion, PV was slightly reduced (60 .+-. 7 to 55 .+-. 6 cm/sec, p < 0.05) while MA was also reduced mildly but significantly (1219 .+-. 109 to 1099 .+-. 109 cm/sec, p < 0.05). Dextran infusion produced a marked increase in PV (48 .+-. 7 to 82 .+-. 13 cm/sec, p < 0.05) while the increase was slightly less for MA (1089 .+-. 95 to 1604 .+-. 109 cm/sec2). The results indicated that inotropic stimulation markedly increased both PV and MA. PV and MA responded slightly but significantly to afterload alterations. (8.3% vs 9.8%, respectively). Both PV and MA increased markedly to the preload increment. Although MA showed the same mild degree of depression with afterload augmentations, its response to preload challenge was less than PV (41% vs 71% increase, respectively). MA may be a better index for left ventricular contractility than is PV, but careful consideration of the loading status should be taken before adopting these parameters into clinical practice.

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Accession: 007252393

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PMID: 1726371

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