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Effect of neonatal thymectomy on d galactosamine induced hepatitis or propionibacterium acnes and lipopolysaccharide induced liver injury in mice



Effect of neonatal thymectomy on d galactosamine induced hepatitis or propionibacterium acnes and lipopolysaccharide induced liver injury in mice



Medical Journal of Hiroshima University 38(6): 1007-1016



To evaluate the various effects of neonatal thymectomy on hepatic injury induced by D-galactosamine (Gal-N) or induced by intravenous infusion of lipopolysaccharide (LPS) 1 week after administration of heat-killed Propionibacterium acnes (P. acnes) in A/J mice, the histological changes in the liver and serum autoantibody to liver-specific membrane lipoprotein (LSP) in normal mice and neonatally thymectomized (NTx) mice were temporally observed. In Gal-N induced liver injury, after development of acute hepatic injury, hepatitis was cured in 1 week after Gal-N administration and autoantibody to LSP remained negative in normal mice. However, in NTx mice, severe mononuclear cell infiltration in the portal area was observed at a high rate even 3 months after Gel-N administration and the serum level of autoantibody to LSP continued to show a high positive value. Mononuclear cell infiltration in the portal area was more severe in NTx mice than in normal mice 3 months after the occurrence of P. acnes and LPS induced liver injury, and the level of autoantibody to LSP was higher in the former than the latter. These results suggest that cure of these liver injuries is delayed by NTx due to sensitization with LSP preparations.

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