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Effect of noradrenaline on current clamped and voltage clamped muscle cells of the guinea pig vas deferens in normal krebs solution






European Journal of Pharmacology 163(1): 181-186

Effect of noradrenaline on current clamped and voltage clamped muscle cells of the guinea pig vas deferens in normal krebs solution

The ionic mechanism underlying the time-dependent alteration in the action potential configuration by noradrenaline (NA) was studied using vas deferens muscle vlotage-clmaped according to the double sucrose gap method. Early exposure to NA enhanced the inward Ca2+ current (ca) by increasing conductance whereas late exposure diminished Ica by reducing the driving force. The degree of increase in the peak outward K+ curent (IK') was higher with a greater enhancement of Ica by NA but the late outward K+ current (IK) was insensitive to NA.

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Accession: 007254833



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