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Effect of tgf beta 1 tgf beta 2 and bfgf on chick cartilage and mouse cell differentiation

Effect of tgf beta 1 tgf beta 2 and bfgf on chick cartilage and mouse cell differentiation

Experimental Cell Research 191(1): 144-148

In insulin containing defined medium TGF-.beta.1, TGF-.beta.2, and bFGF all stimulate chondrogenic differentiation in high-density micromass cultures of distal limb bud mesenchyme cells of chick embryos. In addition bFGF inhibits myogenic differentiation, while TGF-.beta.1 and TGF-.beta.2 appear to have no effect. TGF-.beta.1 and bFGF together act additively to enhance chondrogenesis, while TGF-.beta. blocks the bFGF inhibitory action on myoblasts, thus allowing them to differentiate. In the absence of insulin, the inhibitory effect of bFGF on muscle cell differentiation is reduced; cartilage differentiation in the presence of the above growth factors is also slightly reduced.

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Accession: 007262045

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