EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of tgf beta 1 tgf beta 2 and bfgf on chick cartilage and mouse cell differentiation



Effect of tgf beta 1 tgf beta 2 and bfgf on chick cartilage and mouse cell differentiation



Experimental Cell Research 191(1): 144-148



In insulin containing defined medium TGF-.beta.1, TGF-.beta.2, and bFGF all stimulate chondrogenic differentiation in high-density micromass cultures of distal limb bud mesenchyme cells of chick embryos. In addition bFGF inhibits myogenic differentiation, while TGF-.beta.1 and TGF-.beta.2 appear to have no effect. TGF-.beta.1 and bFGF together act additively to enhance chondrogenesis, while TGF-.beta. blocks the bFGF inhibitory action on myoblasts, thus allowing them to differentiate. In the absence of insulin, the inhibitory effect of bFGF on muscle cell differentiation is reduced; cartilage differentiation in the presence of the above growth factors is also slightly reduced.

(PDF emailed within 1 workday: $29.90)

Accession: 007262045

Download citation: RISBibTeXText



Related references

Effect of TGF-beta 1, TGF-beta 2, and bFGF on chick cartilage and muscle cell differentiation. Experimental Cell Research 191(1): 144-148, 1990

Effect of TGF-b1, TGF-b2, and bFGF on chick cartilage and muscle cell differentiation. Experimental Cell Research 4-8, 1990

Transforming growth factor-beta 1, -beta 2 and -beta 3 in cartilage and bone cells during endochondral ossification in the chick. Development 114(4): 907-911, 1992

The effects of bfgf igd i and tgf beta on rmo skeletal muscle cell proliferation and differentiation. Experimental Cell Research 187(2): 250-254, 1990

Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-beta. Developmental Biology 135(2): 424-430, 1989

Regulation of cyclic adenosine 3' 5' monophosphate dependent protein kinase activity and regulatory subunit rii beta content by basic fibroblast growth factor bfgf during granulosa cell differentiation possible implication of protein kinase c in bfgf action. Biology of Reproduction 47(2): 202-212, 1992

Transforming growth factor-beta and bone morphogenetic protein-2 act by distinct mechanisms to promote chick limb cartilage differentiation in vitro. Developmental Dynamics 200(2): 103-116, 1994

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation. Journal of Experimental Medicine 173(2): 483-486, 1991

TGF-beta and bFGF immunoreactivity in chick eyes. Investigative Ophthalmology & Visual Science 37(3): S478, 1996

The effect of interferon-beta on mouse neural progenitor cell survival and differentiation. Biochemical and Biophysical Research Communications 388(2): 181-186, 2009

Role of the transforming growth factor beta tgf beta family in limb cartilage differentiation. Journal of Cell Biology 111(5 PART 2): 272A, 1990

Opposite effect of stable transfection of bioactive transforming growth factor-beta 1 (TGF beta 1) versus exogenous TGF beta 1 treatment on expression of 92-kDa type IV collagenase in mouse skin squamous cell carcinoma CH72 cells. Molecular Carcinogenesis 19(2): 122-136, 1997