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Effect on renal function of essential fatty acid supplementation in cystic fibrosis



Effect on renal function of essential fatty acid supplementation in cystic fibrosis



Journal of Pediatrics 115(2): 242-250



Changes in renal hemodynamics, sodium homeostasis, renal acidifying capacity, and aldosterone excretion were studied before and after long-term intravenous essential fatty acid supplementation for a period 3 years in 11 patients with cystic fibrosis. The mean (.+-. SD) glomerular filtration rate was high at the start of the study (133 .+-. 18 ml/min/1.73 m2 body surface area) and decreased significantly (p < 0.05) to within normal values after 1 year of essential fatty acid supplementation. The urinary elimination of an oral sodium load initially was very low (3.6 .+-. 2.5 mmol/hr/1.73 m2 body surface area vs control subjects' values of 7.9 .+-. 2.0; p < 0.001) and increased during treatment but was not normalized (p < 0.05 vs control subjects' values). Free water clearance and distal tubular sodium delivery, which were significantly decreased before treatment (p < 0.01 and p < 0.001 vs control subjects' values, respectively) did not increase significantly. The mean urinary aldosterone excretion did not significantly differ from that in control subjects before and after treatment. The acidifying capacity was disturbed, indicating a low renal bicarbonate threshold, and was changed during treatment in only 2 of 10 patients. These data indicate that essential fatty acid deficiency may contribute to the renal disturbances in cystic fibrosis.

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Accession: 007265300

Download citation: RISBibTeXText

PMID: 2754552

DOI: 10.1016/s0022-3476(89)80072-1


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