Section 8
Chapter 7,267

Effects of 4 o benzylphenoxy n methylbutylamine hydrochloride on rat behavior

Nakazato, T.; Akiyama, A.

Biogenic Amines 8(3-4): 199-205


ISSN/ISBN: 0168-8561
Accession: 007266407

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Behavioral changes and the extracellular release of striatal transmitters and ascorbic acid (AA) were examined in freely moving rats using in vivo voltammetry after the intraperitoneal administrations of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016). In addition, the striatal AA content was determined. When MCI-2016 was administered to 6-hydroxydopamine-treated rats and untreated normal rats, behavioral changes were elicited in both groups, but hyperactivity was seen in the treated rats. The striatal dopamine (DA) and serotonin concentrations in the extracellular fluid (ECF) did not increase, but the AA concentration in the ECF increased while the striatal AA content decreased. This indicated that AA was released extracellularly following the administration of MCI-2016. When haloperidol, a DA receptor antagonist, was administered intraperitoneally to normal rats before the injection of MCI-2016, the behavioral changes were suppressed. These results largely suggest that MCI-2016 is an agonist or modulator of the DA receptor.

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