Effects of betaxolol a cardioselective beta adrenoceptor antagonist on kidney function in spontaneously hypertensive rats and dogs

Bessho, H.; Suzuki, J.; Tobe, A.; Sakonjo, H.; Nakanishi J I.; Komatsu, M.; Hirao, R.; Nakajima, S.; Morimoto, M.; Nishimori, T.

Oyo Yakuri 40(2): 111-116


ISSN/ISBN: 0300-8533
Accession: 007269352

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A study was made of the effects of betaxolol, a selective .beta.1-adrenoceptor antagonist with a vasodilating action, on the renal function in conscious, spontaneously hypertensive rats (SHR) and in conscious dogs. Orally administered betaxolol (1-30 mg/kg) dose-dependently increased the urine volume and the urinary excretion of sodium in saline-loaded SHR. On the other hand, atenolol (1-30 mg/kg, p.o.), a selective .beta.1-adrenoceptor antagonist, had hardly any effect on the urine volume or the urinary excretion of electrolytes in SHR. In dogs, intravenously administered betaxolol did not affect either the renal blood flow or the glomerular filtration rate but tended to increase the urine volume. Atenolol (1 mg/kg, i.v.), however, tended to decrease both the renal blood flow and the glomerular filtration rate but had no effect on urine volume in dogs. The results indicate that betaxolol has a diuretic effect in SHR and dogs and that this effect can be attributed in part to its beneficial action on renal hemodynamics.