Effects of nifedipine and verapamil on renin activity levels of ionized calcium and aldosterone in blood plasma and parameters of hemodynamics in spontaneously hypertensive rats

Nasyrov, S.N.; Shvarts, G.Ya; Kukes, V.G.; Faermark, I.F.; Syubaev, R.D.

Farmakologiya i Toksikologiya 53(1): 32-35


Accession: 007280365

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Nifedipine and verapamil (10 mg/kg orally) were found to induce a significant increase of renin activity, a decrease of aldosterone and ionized calcium levels in blood plasma in spontaneously hypertensive rats. A preliminary administration of a hypertonic solution of sodium chloride decreased renin activity, ionized calcium and aldosterone levels that contributed to the enhancement of the hypotensive effect of calcium antagonists. It was established that nifedipine by its effect on the parameters of hemodynamics and the condition of renin-angiotensin system as well as the blood plasma ionized calcium level is superior to verapamil.