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Effects of pituitary beta-endorphin secretagogues on the concentration of beta-endorphin in rat cerebrospinal fluid: evidence for a role of vasopressin in the regulation of brain beta-endorphin release

Effects of pituitary beta-endorphin secretagogues on the concentration of beta-endorphin in rat cerebrospinal fluid: evidence for a role of vasopressin in the regulation of brain beta-endorphin release

Neuroendocrinology 51(1): 104-110

The concentration of .beta.-endorphin-immunoreactivity (.beta.E-iR) in cerebrospinal fluid (CSF) and plasma of rats was determined following intracerebroventricular (CV) treatment of conscious animals with substances known to stimualte the release of .beta.E and other pro-opiomelanocortin (POMC)-derived peptides at the level of the anterior and intermediate lobes of the pituitary. The .beta.-adrenoceptor agonist isoproterenol (ISO) did not influence the concentration .beta.E-IR in CSF collected 5-60 min after ICV administration of doses ranging from 3 to 30,000 pg/rat. Plasma .beta.E-IR levels, however, were significantly increased 20 min following ICV injection of 30,000 pg ISO. ICV treatment of animals with ovine corticotropin-releasing factor (CRF; 30-30,000 pg/rat) also did not affect CSF levels of .beta.E-IR, whereas CRF in a dose of 30 pg significantly decreased, and in doses of 300-30,000 pg enhanced plasma .beta.E-IR concentrations as determined by 20 min following treatments. ICV injection of arginine8-vasopressin (AVP) in doses of 10-1,000 pg/rat dose-dependently elevated the .beta.E-IR concentration in CSF without affecting plasma .beta.E-IR levels. This AVP-induced increase in CSF .beta.E-IR was maximal 20-35 min and .beta.E-IR levels had returned to basal 60 min following treatment. The data indicate that AVP and not ISO and CRF is a stimulator of CSF levels of .beta.E-IR. As .beta.E-IR in CSF likely originates from brain POMC neurons, these results suggest the hot vasopressin may be a physiological regulator of brain POMC activity, and may act as a releasing factor for POMC-derived peptides in the brain.

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Accession: 007282095

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PMID: 2137562

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