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Epidermal and dermal effects of epidermal growth factor during wound repair


Epidermal and dermal effects of epidermal growth factor during wound repair



Journal of Investigative Dermatology 94(5): 624-629



ISSN/ISBN: 0022-202X

PMID: 2324518

DOI: 10.1111/1523-1747.ep12876204

Epidermal growth factor (EGF), a well-characterized peptide that stimulates in vitro cell proliferation, has now been shown to enhance in vivo resurfacing of porcine wounds. Topical formulations containing either recombinant EGF or placebo were applied daily to partial-thickness wounds along the dorsal surface of pigs. Following full-thickness removal of these wounds, tissues were sectioned and stained, and histologic sections were subjected to computerized morphometric analysis. A significant acceleration of epithelialization across the wound surface was noted following daily EGF treatments. EGF delivered in a variety of tropical formulations also produced a marked increase in the cellularity and thickness in the neodermis. A dose-responsive increase in the thickness of the granulation tissue was also observed. In conclusion, topical application of EGF stimulates epithelialization of partial-thickness wounds and produces a positive impact on the underlying dermis during the early phases of wound repair.

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Accession: 007308881

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