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Evaluation of the yield stress of normal blood as a function of fibrinogen concentration and hematocrit

Evaluation of the yield stress of normal blood as a function of fibrinogen concentration and hematocrit

Microvascular Research 37(3): 323-338

The yield stress is a sensitive index of blood fluidity at low shear. Seven healthy adults were studied at hematocrits varying between 40 and 80% and fibrinogen concentrations from 0.0 to 0.935 g/dl. Multivariate analysis was used to determine the functional dependence of yield stress on hematocrit and fibrinogen level. The major findings from this analysis include a decreasing effect of fibrinogen at high concentrations (saturation effect), a relative insensitivity of yield stress to fibrinogen at low concentration (threshold effect), and a strong interaction between the effects of hematocrit and fibrinogen concentration on yield stress. Our results give the normal range of yield stress for a given value of fibrinogen and hematocrit and can be used to predict the effect of reductions in hematocrit or fibrinogen on the yield stress of normal blood.

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Accession: 007322816

Download citation: RISBibTeXText

PMID: 2733604

DOI: 10.1016/0026-2862(89)90050-2

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