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Experimental poisoning of goats by vernonia mollissima compositae



Experimental poisoning of goats by vernonia mollissima compositae



Pesquisa Veterinaria Brasileira 7(3): 67-77



The aerial parts of Vernonia mollissima, a plant of the family Compositae, were given orally to 17 goats. An acute lethal poisoning was reproduced by the administration of single doses from 2.5 to 10 g of the plant material per kg body weight. The clinical manifestations of the poisoning were: anorexia, apathy, rumen atony, staggering gait, sternal-abdominal decubitus, hepatic sensibility, sometimes violent muscular contractions, hypothermia and death. The main post-mortem findings were observed in the liver, characterized by severe hepatic distrophy. Histological examinations revealed massive necrosis of the liver parenchyma in the animals with a clinical course of less than 24 hours. In the animals with a longer course (about 48 hours), disappearance of the hepatic cells and congestion in the center of the lobule were observed; the midlobular and peripheral parenchymal cells were swollen and vacuolized. Additionally, there were lesions in the kidneys, which consisted of regressive changes of the epithelial cells of the uriniferous tubules; they were slight in the animals with a clinical course of less than 24 hours, pronounced in the animals with a longer course. In the present investigation also data were obtained concerning the elevation of seric activity of alanine amino transferase (ALT), aspartate amino transferase (AST), lactic dehydrogenase (LDH), gamma-glutamyl transferase (GGT) and alkaline phosphatase (SAP), as well as those regarding the bilirubin and protein levels.

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Accession: 007331953

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