+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Expression of mrnas encoding alpha and beta subunit isoforms of the sodium potassium atpase in the rat cochlea



Expression of mrnas encoding alpha and beta subunit isoforms of the sodium potassium atpase in the rat cochlea



Molecular & Cellular Neuroscience 2(2): 179-187



The distributions of mRNAs coding for three different isoforms of the .alpha. and two of the .beta. subunits of Na,K-ATPase were studied in the rat cochlea using in situ mRNA hybridization. The .alpha.1 and .beta.1 subunit isoforms were widely distributed and appear to mediate the Na and K transport needs of most cochlear cells. The mRNAs encoding the .alpha.2 and .alpha.3 subunit isoforms were present in glial and neuronal types, respectively. The only subunit isoform mRNAs found in the stria vascularis were .alpha.1 and .beta.2. This suggests that Na,K-ATPase consisting of the .alpha.1 and .beta.2 subunits plays a critical role in the maintenance of high extracellular K+ levels in the cochlear endolymph and appears to transport K+ ions against very low levels of intracellular potassium.

(PDF emailed within 1 workday: $29.90)

Accession: 007336156

Download citation: RISBibTeXText


Related references

Expression of mRNAs encoding alpha and beta subunit isoforms of the Na,K-ATPase in the rat cochlea. Molecular and Cellular Neurosciences 2(2): 179-187, 1991

Expression of mRNAs encoding α and β subunit isoforms of the Na,K-ATPase in the rat cochlea. Molecular and Cellular Neuroscience 2(2): 179-187, 1991

Expression of mRNAs encoding alpha and beta subunit isoforms of Na,K-ATPase in the vestibular labyrinth and endolymphatic sac of the rat. Molecular and Cellular Neurosciences 5(6): 604-613, 1994

Cell-specific expression of mRNAs encoding Na+,K(+)-ATPase alpha- and beta-subunit isoforms within the rat central nervous system. Proceedings of the National Academy of Sciences of the United States of America 88(16): 7425-7429, 1991

Tissue distribution of messenger rnas encoding the alpha isoforms and beta subunit of rat sodium potassium atpase. Biochemical & Biophysical Research Communications 145(1): 52-58, 1987

Localization of mRNAs encoding sodium, potassium-ATPase subunit isoforms in rat kidney using RT-PCR. Journal of the American Society of Nephrology 3(3): 805, 1992

Expression of alpha subunit and beta subunit isoforms of the sodium potassium atpase in the nervous system. Journal of General Physiology 96(6): 65A, 1990

Tissue distribution of mRNAs encoding the alpha isoforms and beta subunit of rat Na+,K+-ATPase. Biochemical and Biophysical Research Communications 145(1): 52-58, 1987

Expression of mRNAs encoding the alpha-1 and the beta-1 subunits sodium, potassium ATPase in human lymphocytes activated with phytohaemagglutinin. FEBS (Federation of European Biochemical Societies) Letters 316(1): 37-40, 1993

Segmental localization of mRNAs encoding Na(+)-K(+)-ATPase alpha- and beta-subunit isoforms in rat kidney using RT-PCR. Kidney International 46(3): 627-638, 1994

Differential expression patterns of sodium potassium ATPase alpha and beta subunit isoforms in mouse brain during postnatal development. Neurochemistry International 2019, 2019

Sodium ion potassium ion atpase alpha alpha 1 alpha 2 alpha 3 and beta beta 1 beta 2 subunit isoforms reveal regional cellular and subcellular differences along the ocular ciliary epithelium. Investigative Ophthalmology & Visual Science 32(4): 1185, 1991

Differential expression and cellular distribution of mRNAs encoding alpha- and beta-isoforms of Na(+)-K(+)-ATPase in rat kidney. American Journal of Physiology 265(6 Pt 2): F792-F801, 1993

Expression of beta subunit isoforms of the sodium, potassium-ATPase is muscle type-specific. FEBS (Federation of European Biochemical Societies) Letters 328(3): 253-258, 1993

Expression of dna encoding alpha beta and gamma polypeptides of sodium potassium atpase in yeast does gamma have a function in sodium potassium atpase activity. Journal of General Physiology 96(6): 22A, 1990