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Fatty acids and disease part 2. a study of the effect of unsaturated fatty acid isomers includes trans fatty acids in edible lipids which compete with essential fatty acids for desaturase enzymes as measured by chick growth and essential fatty acid metabolism in chicks and rats



Fatty acids and disease part 2. a study of the effect of unsaturated fatty acid isomers includes trans fatty acids in edible lipids which compete with essential fatty acids for desaturase enzymes as measured by chick growth and essential fatty acid metabolism in chicks and rats



South African Journal of Dairy Science 21(2): 31-40



Experiments were carried out to assess the effects of edible lipids containing non-essential unsaturated fatty acids, including the trans fatty acids, on the metabolism of essential fatty acids in rats and chicks fed diets sufficient in essential fatty acids and other essential nutrients. The lipids and their fatty acids of concern under test were milkfat with oleic acid (18.0% of lipid) and a small amount of other 18:1 isomers (about 3.3%); hydrogenated oils with high concentrations (40-50%) of various 18:1 isomers and low concentrations (0.15-3.5%) of 18:2 (trans) isomers and refined vegetable oils with 2.5-3.5% of 18:2 (trans) isomers. This was firstly studied in a chick growth trial and growth of their tissue, and secondly by the synthesis of the proportion of essential fatty acid metabolites and non-essential 20:3 n9 in the livers and other tissue of both chicks and rats. No effect on chick growth due to an inhibition in essential fatty acid metabolism was found. The tissue weights of livers, hearts and kidneys did not differ, but those of the spleen were significantly lower in those chicks receiving hydrogenated oils in their diets. Chicks and rats receiving diets containing these non-essential unsaturated fatty acids did synthesize proportionally less of the essential fatty acid metabolites and rats more of the non-essential 20:3n9. This was specifically noticeable in chicks and rats receiving feeds which contained hydrogenated oil products.

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Fatty acids and disease. II. A study of the effect of unsaturated fatty acid isomers (includes trans fatty acids) in edible lipids which compete with essential fatty acids for desaturase enzymes, as measured by chick growth and essential fatty acid metabolism in chicks and rats. Suid Afrikaanse Tydskrif vir Suiwelkunde 21(2): 31-40, 1989

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