+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Fetomaternal transfusion depends on amount of chorionic villi aspirated but not on method of chorionic villus sampling



Fetomaternal transfusion depends on amount of chorionic villi aspirated but not on method of chorionic villus sampling



American Journal of Obstetrics and Gynecology 162(5): 1185-1188



Transcervical and transabdominal chorionic villus sampling are believed, on the basis of indirect evidence, to result in fetomaternal transfusion. We sought to measure this phenomenon by devising a simple method that would allow us to identify variables that influence fetomaternal transfusion. We investigated patients undergoing transcervical-chorionic villus sampling (n = 15) and transabdominal-chorionic villus sampling (n = 15), restricting the sample to subjects who required only a single catheter passage or needle insertion to obtain villi. Maternal serum .alpha.-fetoprotein was measured before and after the procedure along with .alpha.-fetoprotein concentration of the transport medium into which the villi had been aspirated. We first confirmed that the change in maternal serum .alpha.-fetoprotein levels after chorionic villus sampling, an indirect measure of fetomaternal transfusion, was indeed correlated with the .alpha.-fetoprotein concentration of transpor medium into which the villi were aspirated (p = 0.0350). Fetomaternal transfusion next proved to be correlated with the amount of villi obtained (p = 0.0279). However, when adjusted for the amount of villi obtained, no significant difference was observed between transcervical and transabdominal-chorionic villus sampling with respect to be change in maternal serum .alpha.-fetoprotein levels after chorionic villus sampling (p = 0.8512). These data suggest that the magnitude of fetomaternal transfusion depends on the amount of villi obtained but not on the chorionic villus sampling method used.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 007348583

Download citation: RISBibTeXText

PMID: 1692666


Related references

Fetomaternal transfusion depends on amount of chorionic villiaspirated but not on method of chorionic villus sampling. American Journal of Obstetrics and Gynecology 162(5): 1185-1188, 1990

Fetomaternal transfusion as a result of transabdominal chorionic villus sampling. Archives of Gynecology & Obstetrics 249(Suppl.): S136, 1991

Fetomaternal transfusion following chorionic villus sampling measured by maternal serum alpha fetoprotein sampling. American Journal of Human Genetics 39(3 Suppl.): A255, 1986

Increased nuchal translucency and decreased fetomaternal transfusion after chorionic villus sampling. Ultrasound in Obstetrics and Gynecology 21(5): 455-458, 2003

Risk of Fetomaternal Transfusion After Chorionic Villus Sampling Quantitated by Kleihauer-Betke Stain. American Journal of Human Genetics 55(3 Suppl. ): A284, 1994

Investigations of chorionic villi after chorionic villus sampling (CVS). Correlation of morphological with clinical and laboratory data. Human Genetics 81(4): 329-334, 1989

Modeling chorionic villus sampling technique: influence of number of needle 'passes' on quantity of chorionic villi obtained. Ultrasound in Obstetrics and Gynecology 41(5): 592-593, 2013

Sampling success and risk by transabdominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis: a randomized study. Ultrasound in Obstetrics and Gynecology 1(2): 86-90, 1991

Fetal loss following invasive prenatal testing: a comparison of transabdominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis. Journal of Perinatal Medicine 45(2): 193-198, 2017

A randomized comparison of transcervical and transabdominal chorionic-villus sampling. The U.S. National Institute of Child Health and Human Development Chorionic-Villus Sampling and Amniocentesis Study Group. New England Journal of Medicine 327(9): 594-598, 1992

Does chorionic villus sampling cause fetomaternal haemorrhage?. Lancet 1(8430): 691, 1985

Adverse pregnancy outcome following post-chorionic villus sampling amniocentesis compared to chorionic villus sampling. Journal of Obstetrics and Gynaecology Research 26(3): 209-213, 2000

Fetomaternal hemorrhage in relation to chorionic villus sampling revisited. Prenatal Diagnosis 26(3): 201-205, 2006

Developmental origin of chorionic villus cultures from spontaneous abortion and chorionic villus sampling. Journal of Obstetrics and Gynaecology Canada 33(5): 449-452, 2011

Vaginosonographic guided chorionic villi needle biopsy (transvaginal chorionic villi sampling). European Journal of Obstetrics Gynecology and Reproductive Biology 23(5-6): 315-319, 1986