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Homology among eleven flavivirus by comparative nucleotide sequence of genomic rnas and deduced amino acid sequences of viral proteins



Homology among eleven flavivirus by comparative nucleotide sequence of genomic rnas and deduced amino acid sequences of viral proteins



Tropical Medicine 33(1-2): 23-33



Homology among 11 flaviviruses was compared by nucleotide sequence of genomic RNAs, and deduced amino acid sequences of viral proteins. Overall amino acid homology was higher among the viruses in the same (66-90%) than those in different subgroups (39-51%). In a subgroup consisting Japanese encephalitis (JE), West Nile (WN), Kunjin (KUN), Murray Valley encephalitis (MVE), and St. Louis encephalitis (SLE) viruses, homology of the core protein (C) was less than that of the envelope glycoprotein (E). Homology of the nonstructural proteins was also higher among the viruses belonging to the same than those in different subgroups. The results suggested that selection by the neutralizing antibodies was not the determinant factor for the evolution and differentiation of these viruses. High homology of NS3 and particularly NS5 nonstructural proteins than other viral proteins indicated their vital role in viral replication process. Nucleotide sequence homology in the 3'- and 5'-noncoding region did not reflect serological relationships of flaviviruses, although several conserved sequences were present in these regions.

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